Assessment of exposure to diisocyanates in the work environment
Authors:
P. Matejíčeková; M. Kizeková; M. Matejová; Ľ. Legáth
Authors place of work:
Klinika pracovného lekárstva a klinickej toxikológie UPJŠ a UNLP v Košiciach, prednosta prof. MUDr. Ľubomír Legáth, PhD.
Published in the journal:
Pracov. Lék., 74, 2022, No. 3-4, s. 51-56.
Category:
Review Papers
Summary
Exposure to diisocyanates is associated with the development and increased risk of occupational respiratory diseases – allergic rhinitis, bronchial asthma and hypersensitivity pneumonitis. The assessment of exposure to isocyanates in the work environment is based on the measurement of their concentration in the air. In addition to this method, biological monitoring is also used to assess occupational exposure to isocyanates. This process is based on the determination of concentration of isocyanate metabolism products in biological material, mostly corresponding diamines in urine. Several foreign studies have investigated the correlation between the results of isocyanates monitoring in work environment and biological monitoring. The results of the studies show that workers are exposed to isocyanates by inhalation as well as by the dermal route. The results also indicate that the analysis of diamines in biological material is suitable method for assessing overall exposure, which includes all exposure pathways and could contribute to reducing the level of exposure to isocyanates in the workplace.
Keywords:
diisocyanates – professional exposure – biological monitoring
Zdroje
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Štítky
Hygiene and epidemiology Hyperbaric medicine Occupational medicineČlánok vyšiel v časopise
Occupational Medicine
2022 Číslo 3-4
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