Primary (spindle cell) Rhabdomyosarcoma of Submandibular Salivary Gland
Authors:
Z. Kinkor 1; M. Kracík 2; A. Skálová 1
Authors place of work:
Bioptická laboratoř, s. r. o., Plzeň
; vedoucí prof. MUDr. A. Skálová, CSc.
Oddělení otorinolaryngologie, Oblastní nemocnice Jičín
1; vedoucí prim. MUDr. M. Kracík
2
Published in the journal:
Otorinolaryngol Foniatr, 58, 2009, No. 2, pp. 106-109.
Category:
Case History
Summary
Presented is an extremely rare case of the primary spindle cell rhabdomyosarcoma of submandibular gland in 55-year-old man. The multilobular tumorous mass measured up to 45 mm in maximum diameter, completely obliterated submandibular gland and extended into surrounding soft tissues. There was massive metastatic disease in the regional cervical lymph nodes at the time of diagnosis; the patient developed systemic dissemination in the lung, mediastinal lymph nodes and vertebral column three months after operation. Radiological, macroscopic and histological findings are broadly documented. Microscopy consisted of monotonous, fascicular spindle cell pattern lacking any organoid structures or epithelial formations. Furthermore, there was no clear-cut evidence of histogenetic orientation of the lesion by conventional hematoxylin-eosin stain. Immunohistochemistry confirmed diagnosis of rhabdomyosarcoma by expression of desmin and MyoD1. Discussed are both current rhabdomyosarcoma classification and its differential diagnosis in the background of spindle cell proliferations of salivary glands.
Key words:
submandibular salivary gland, sarcoma, primary spindle cell rhabdomyosarcoma.
Zdroje
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Štítky
Audiology Paediatric ENT ENT (Otorhinolaryngology)Článok vyšiel v časopise
Otorhinolaryngology and Phoniatrics
2009 Číslo 2
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