Endoscopic Autofluorescence for Diagnosis of Laryngeal Tumors

Česká verzia

Authors: V. Kavečanský; N. Lukán ¹
Authors place of work: ORL oddelenie ORL Humenné, s. r. o. primár MUDr. I. Hriseňko IV. interná klinika LF UPJŠ Košice ; prednosta prof. MUDr. I. Tkáč, Ph. D. ¹
Published in the journal: Otorinolaryngol Foniatr, 59, 2010, No. 4, pp. 225-229.
Category: Comprehensive Reports

Summary

The success of laryngeal cancer treatment is influenced by many factors. In addition to decreased incidence due to improvement of public education, regimen, and the use of a functional system of patient follow-up examination, early and precise diagnosis represents the medical decisive factor.

The optical examination of larynx by means of autofluorescence has been implicated among the new methods of examination over the last years. In the ENT outpatient practice this new method of examination helps to differentiate benign lesions from the potentially malignant foci. For a surgeon dealing with ORL oncology it is important for a precise localization of the tumorous focus, which enables optimization of surgical treatment and in this way minimizes mutilation.

The endoscopic autofluorescence is a non-invasive, simple and economically undemanding examination, which can significantly improve early diagnosis of laryngeal tumors. In spite of the fact that this method requires special technical equipment, it can be executed in outpatient conditions without general anesthesia with a markedly short time for examination. The sensitivity of the examination reaches almost 100% and specificity in larynx cancer diagnosis is between 60% and 90%. There are no complications in the meaning of photosensitivity or allergic reactions.

Key words:
autofluorescence, endoscopy, diagnostics, carcinoma of larynx

Zdroje

1. Alfano, R. R., Tata, D. B., Cordero, J., Tomashefsky, P., Longo, F.W., Alfano, M. A.: Laser-induced fluorescence spectroscopy from native cancerous and normal tissue. IEEE J. Quant Electron, 1984, č. 12, s. 1507-1511.

2. Arens, C., Dreyer, T., Glanz, H., Malzahn, K.: Indirect autofluorescence laryngoscopy in the diagnosis of laryngeal cancer and its precursor lesions. Eur Arch. Otorhinolaryngol, roč. 261, 2004, č. 2, s. 71-76.

3. Arens, C., Reussner, D., Woenckhaus, J., Leunig, A., Betz, C. S., Glanz, H.: Indirect fluorescence laryngoscopy in the diagnosis of precancerous and cancerous, laryngeal lesions. Eur Arch. Otorhinolaryngol, roč. 264, 2007, č. 6, s. 621-626.

4. Arens, C., Glanz, H., Woenckhaus, J., Hersemeyer, K., Kraft, M.: Histologic assessment of epithelial thickness in early laryngeal cancer or precursor lesions and its impact on endoscopic imaging. Eur Arch. Otorhinolaryngol, roč. 264, 2007, č. 6, s. 645-649.

5. Arens, C., Reussner, D., Neubacher, H., Woenckhaus, J., Glanz, H.: Spectrometric measurement in laryngeal cancer. Eur Arch. Otorhinolaryngol, roč. 263, 2006, č. 11, s. 1001-1007.

6. Betz, C. S., Arens, C., Leunig A.: Autofluorescence diagnosis of cancers of the upper aerodigestive tract. Tuttlingen, Endo-Press, 2007, 38 s.

7. Csanády, M., Kiss, J. G., Iván, L., Jóri, J., Czigner, J.: ALA (5-aminolevulinic acid)-induced protoporphyrin IX fluorescence in endoscopic diagnostic and control of pharyngo-laryngeal cancer. Eur Arch. Otorhinolaryngol, roč. 261, 2004, č. 5, s. 262-266.

8. Epstein, J. B., Scully, C., Spinelli, J.: Toluidine blue and Lugol’s iodine application in the assessment of oral malignant disease and lesions at risk of malignancy. J. Oral Pathol. Med., roč. 21, 1992, č. 4, s. 160-163.

9. Harris, D. M., Hill, J. H., Werkhaven, J. A., Applebaum, E. L., Lobraico, R. V., Waldow, S. M.: Porphyrin fluorescence and photosensitization in head and neck cancer. Arch. Otolaryngol Head Neck Surg., roč. 112, 1986, č. 11, s. 1194-1199.

10. Kennedy, J. C., Pottier, R. H., Pross, D. C.: Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J. Photochem Photobiol B, roč. 6, 1990, č. 1-2, s. 143-148.

11. Kurita, H., Kurashina, K.: Vital staining with iodine solution in delineating the border of oral dysplastic lesions. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., roč. 81, 1996, č. 3, s. 275-280.

12. Leonard, J., Beck, W.: Hematoporphyrin fluorescence: an aid in diagnosis of malignant neoplasmas. Laryngoscope, roč. 81, 1971, č. 3, s. 365-372.

13. Mehlmann, M., Betz, C. S., Stepp, H., Arbogast, S., Baumgartner, R., Grevers, G., Leunig, A.: Fluorescence staining of laryngeal neoplasms after topical application of 5-aminolevulinic acid: preliminary results. Lasers Surg. Med., roč. 25, 1999, č. 5, s. 414-420.

14. Morgenroth, K.: Neue Untersuchungen mit dem Kolposkop nach Hinselmann und der Vitalfärbung der Mundschleimhaut zur Fruhdiagnose von Tumoren im Kieferbereich. Dtsch Zahnaerztl Z 2, roč. 12, 1957, č. 3, s. 192-201.

15. Mostafa, B. E., Shafik, A. G., Fawaz, S.: The role of flexible autofluorescence laryngoscopy in the diagnosis of malignant lesions of the larynx. Acta Otolaryngol, roč. 127, 2007, č. 2, s. 175-179.

16. Paczona, R., Temam, S., Janot, F., Marandas, P., Luboinski, B.: Autofluorescence videoendoscopy for photodiagnosis of head and neck carcinoma. Eur Arch. Otorhinolaryngol, roč. 260, 2003, č. 10, s. 544-548.

17. Richart, R. M.: A clinical staining test for the in vivo delineation of dysplasia and carcinoma-in-situ. Am. J. Obstet. Gynecol., roč. 86, 1963, č. 1, s. 703-712.

18. Sabes, W. R., Singer, R. E., Kuhn, T.: Effectiveness of toluidine blue as an aid to biopsy in the diagnosis of DMBA-induced hamster pouch dysplasia and carcinoma. Cancer, roč. 29, 1972, č. 6, s. 1584-1589.

19. Zargi, M., Smid, L., Fajdiga, I., Bubnic, B., Lenarcic, J., Oblak, P.: Detection and localization of early laryngeal cancer with laser-induced fluorescence: preliminary report. Eur Arch. Otorhinolaryngol, roč. 254, 1997, Suppl 1, s. 113-116.