The Significance of Galectin-3 Expression in Glottic Laryngeal Squamous Cell Carcinoma
Authors:
D. Kalfeřt 1,2; P. Čelakovský 1; D. Ludvíková 3,4
Authors place of work:
Klinika otorinolaryngologie a chirurgie hlavy a krku, Univerzita Karlova v Praze, Lékařská fakulta v Hradci Králové, Fakultní nemocnice Hradec Králové
1; Klinika ORL, foniatrie, sluchová protetika, s. r. o., Plzeň
2; Ústav biologie, Univerzita Karlova v Praze, Lékařská fakulta v Plzni
3; Ústav patologie, Univerzita Karlova v Praze, 1. lékařská fakulta, Všeobecná fakultní nemocnice v Praze
4
Published in the journal:
Otorinolaryngol Foniatr, 65, 2016, No. 2, pp. 76-81.
Category:
Original Article
Summary
Introduction:
The aim of our study was to assess the significance of galectin-3 expression in glottic laryngeal squamous cell carcinoma in relation to the clinicopathological parameters.
Material and methods:
Retrospective study. The study included 58 patients who had undergone surgical resection glottic laryngeal squamous cell carcinoma at The Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital in Hradec Kralove, during the years 2001–2009. Paraffin-embedded blocks of all studied carcinomas were retrieved from archive file of The Fingerland Department of Pathology, University Hospital in Hradec Kralove. Subsequently, galectin-3 expression was detected in all carcinomas. The results of expression were statistically analyzed in relation to clinicopathological parameters.
Results:
Galectin-3 was expressed in 31 (53.5%) patients. Galectin-3 expression did not statistically correlate with clinicopathological parameters.
Conclusion:
The role of galectin-3 expression in glottic laryngeal squamous cell carcinoma remains unclear. Although in accordance with the results of recent studies, it is possible for said marker seen as a potential prognostic and predictive and should be the subject of further studies.
KEYWORDS:
galectin-3, squamous cell carcinoma of the larynx, glottic
Zdroje
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Štítky
Audiology Paediatric ENT ENT (Otorhinolaryngology)Článok vyšiel v časopise
Otorhinolaryngology and Phoniatrics
2016 Číslo 2
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