Use of Local Hemostyptic Drugs in Liver Resections

Česká verzia

Authors: R. Šefr; J. Silák; M. Ondrák; L. Fiala
Authors place of work: Chirurgické oddělení, Masarykův onkologický ústav Brno, primář MUDr. Vojtech Chrenko, CSc.
Published in the journal: Rozhl. Chir., 2009, roč. 88, č. 6, s. 337-341.
Category: Monothematic special - Original

Summary

Introduction:
Bleeding during and following liver resection continues to be an object of surgeon’s attention and a potential source of significant morbidity. Topical hemostatic agents are used during surgical intervention when conventional methods are not sufficient because of the site of surgery or degree of bleeding. A variety of agents with different effects is now available.

Aim:
To verify the efficacy and safety of cellulose based local hemostat during liver resections.

Methods:
In 67 cases of liver resection the surface was covered by Traumacel TAF net which was left in place.

Results and conclusion:
There were no postoperative bleeding in this group of patients. No other serious complication has been observed. Traumacel is a safe and effective local hemostat during liver resetions.

Key words:
hemostasis – liver resection – local hemostatic agents

Zdroje

1. Grundmann, R. T., Hermanek, P., Merkel, S., et al. Diagnostik und Therapie von Lebermetastasen kolorektaler Karzinome – Workflow. Zentralbl. Chir., 2008; 133: 267–284.

2. Berrevoet, F., Hemptinne, B. Use of topical hemostatic agents during liver resection. Dig. Surg., 2007; 24: 288–293.

3. Delis, S. G., Madariaga, J., Bakoyannis, A., Dervenis, C. Current role of bloodless liver resection. World J. Gastroenterol., 2007; 13: 826–829.

4. Erdogan, D., Busch, O. R. C., Gouma, D. J., Gulik, T. M.: Prevention of biliary leakage after partial liver resection using topical hemostatic agents. Dig. Surg., 2007; 24: 294–299.

5. Spotnitz, W.D., Bursk, S.: Hemostats, sealants, and adhesives: components of the surgical toolbox. Transfusion, 2008; 48: 1502–1516.

6. Gabay, M. Absorbable hemostatic agents. Am. J. Health Syst. Pharm., 2006; 63: 1244–1253.

7. Seyednejad, H., Imani, M., Jamieson, T., Seifalian, A. M. Topical haemostatic agents. Brit. J. Surg., 2008; 95: 1197–1225.

8. Smrčka, M. Použití oxicelulózy v neurochirurgii – technické poznámky. Rozhl. Chir., 2001; 80: 112–115.

9. Hofman, D., Wilson, J., Poore, S., et al. Can Traumacel be used in the treatment of chronic wounds? J. Wound Care, 2000, 9: 393–396.

10. Palm, M. D., Altman, J. S.: Topical hemostatic agents: a review. Dermatol. Surg., 2008; 34: 431–445.

11. Kitamura, K., Yasuoka, R., Ohara, M., et al. How safe are xenogeneic hemostats – report of a case of severe systemic allergic reaction. Surg. Today, 1995; 25: 433–435.

12. Brodbelt, A. R., Miles, J. B., Foy, P. M., Broome, J. C. Intra- spinal oxidised cellulose (Surgicel®) causing delayed paraplegia after thoracotomy – a report of three cases. Ann. R. Coll. Surg. Engl., 2002; 84: 97–99.

13. Cheng, C. M., Meyer-Massetti, C., Kayser, S. R.: A review of three stand-alone topical thrombins for surgical hemostasis. Clin. Ther., 2009; 31: 32–41.

14. Frilling, A., Stavrou, G. A., Mischinger, H. J., et al. Effectiveness of a new carrier-bound fibrin sealant versus argon beamer as a haemostatic agent during liver resection: a randomised prospective trial. Langenbecks Arch. Surg., 2005; 390: 114–120.

15. Schwartz, M., Madagriaga, J., Hirose, R., et al. Comparison of a new fibrin sealant with standard topical hemostatic agents. Arch. Surg., 2004; 139: 1148–1154.

16. Izzo, F., Giacomo, R., Falco, P., et al. Efficacy of a haemostatic matrix for the management of bleeding in patients undergoing liver resections: results from 237 cases. Curr. Med. Res. Opin., 2008; 24: 1011–1015.

17. Figueras, J., Llado, J., Miro, M., et al. Application of fibrin glue sealant after hepatectomy does not seem justified: results of a randomized study in 300 patients. Ann. Surg., 2007; 245: 536–542.

18. Chapman, W. C., Clavien, P. A., Fung, J., et al. Effective control of hepatic bleeding with a novel collagen-based composite with autologous plasma:results of a randomized controlled trial. Arch. Surg., 2000; 129: 445–450.

19. Kheirabadi, B.S., Field-Riley, A., Pearson, R., et al.: Comparative study of the efficacy of the common topical hemostatic agents with fibrin sealant in a rabbit aortic anastomosis model. J. Surg. Res., 2002; 106: 99–107.