Vascular Prostheses: 50 years of Advancement from Synthetic towards Tissue Engineering and Cell Therapy

Česká verzia

Authors: J. Chlupáč ^1,2,3; E. Filová ^1,2; L. Bačáková ^1,2
Authors place of work: Oddělení růstu a diferenciace buněčných populací, Fyziologický ústav, Akademie věd ČR, v. v. i., Praha, Česká republika, přednostka: MUDr. Lucie Bačáková, CSc. ¹; Centrum výzkumu chorob srdce a cév, Akademie věd ČR, v. v. i., Praha, Česká republika ²; Klinika transplantační chirurgie, Institut klinické a experimentální medicíny – IKEM, Praha, Česká republika, přednosta: prof. MUDr. Miloš Adamec, CSc. ³
Published in the journal: Rozhl. Chir., 2010, roč. 89, č. 1, s. 85-94.
Category: Monothematic special - Original

Summary

Since more than 50 years, the gold standard in synthetic vascular prostheses has been represented by polyethylene terephtalate (PET, Dacron) and expanded polytetrafluoroethylene (ePTFE). These polymers perform well as sustitutes of large-caliber vessels, however, their long-term patencies are disappointing in small-caliber applications (< 6 mm). Thus, patient’s own artery or vein remains the material of choice in coronary, crural or microvessel bypass surgery. Synthetic materials fail due to thrombosis and insufficient healing process that consists in highly incomplete endothelial cells coverage and intimal hyperplasia caused by compliance mismatch and hemodynamic imbalance. To find better small-caliber vascular graft, surgical techniques have been modified, novel biomaterials have been investigated and cell and tissue culture technologies have been adopted. Partly or fully tissue-engineered vascular grafts have been produced and experimentally and clinically evaluated with some promising result. The aim of this review is to briefly list currently used and examined vascular graft materials with special attention to cell/biomaterial ineractions, tissue engineering and authors’ own experience.

Key words:
blood vessel prosthesis – polyethylene terephtalate – polytetrafluoroethylene – polyurethanes – endothelial cells – tissue engineering

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