Experimental Use of the Recipient’s Epithelial Cells in Tracheal Allotransplantation – Initial Outcomes

Česká verzia

Authors: J. Belák ¹; M. Kudláč ¹; V. Ledecký ¹; J. Rosocha ²; R. Tkáčová ³; Z. Ševčíková ⁵; I. Čavarga ⁴; A. Somoš ⁴
Authors place of work: II. chirurgická klinika, UPJŠ, LF, Košice, Slovenská republika, prednosta: doc. MUDr. J. Belák, PhD. ¹; Klinika malých zvierat, Univerzita veterinárskeho lekárstva a farmácie, Košice, Slovenská republika, prednosta: doc. MVDr. A. Trbolová, PhD. ²; Združená tkanivová banka, UPJŠ, LF, Košice, Slovenská republika, prednosta: MVDr. J. Rosocha, CSc. ³; Klinika pneumológie a ftizeológie, UPJŠ, LF, Košice, Slovenská republika, prednosta: prof. MUDr. R. Tkáčová, DrSc. ⁴; Ústav patologickej anatómie, Univerzita veterinárskeho lekárstva a farmácie, Košice, Slovenská republika, vedúci ústavu: prof. MVDr. M. Levkut, DrSc. ⁵
Published in the journal: Rozhl. Chir., 2011, roč. 90, č. 11, s. 621-624.
Category: Monothematic special - Original

Summary

The management of long tracheal lesions requires development of tracheal implants, which would enable resection combined with anastomosis. The authors’ scientific study is based on tracheal allotransplantation on an animal model (sheep), using tracheal epithelial cells of the recipient. The project covers preparation of the graft, so that all components of the major histocompatibility complex (MHC), which participate in graft rejection, are removed.

Histological examination of the allograft with cultivated epithelial cells showed its good healing with revasculatization and with no signs of graft rejection.

Key words:
surgery – trachea – allotransplantation

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