Kidney transplantation from donors dying of methanol intoxication
Authors:
I. Guňka 1,2; J. Samlík 2; M. Mazur 1,2; E. Pokorná 3; M. Kuman 4; M. Kubišová 5
Authors place of work:
Chirurgická klinika FN Ostrava a Lékařská fakulta Ostravské univerzity
přednosta: Doc. MUDr. P. Zonča, Ph. D., FRCS
1; Transplantační centrum, FN Ostrava, Vedoucí lékař: MUDr. J. Samlík
2; Transplantcentrum IKEM, přednosta: MUDr. P. Trunečka, CSc.
3; Centrum kardiovaskulární a transplantační chirurgie Brno, vedoucí centra: MUDr. V. Mejzlík
4; III. interní gerontometabolická klinika FN Hradec Králové, přednosta: Prof. MUDr. L. Sobotka, CSc.
5
Published in the journal:
Rozhl. Chir., 2013, roč. 92, č. 4, s. 201-204.
Category:
Original articles
Summary
Introduction:
Intoxicated patients represent only a minimum of the total number of cadaveric donors; however, their significance within the transplant program in the Czech Republic has recently been emphasized in connection with the so-called methanol affair.
Material and methods:
A retrospective analysis of methanol-poisoned patients who were declared brain-dead and subsequently underwent organ removal for transplantation purposes in the University Hospital Ostrava was performed. In cooperation with other transplant centres (Institute for Clinical and Experimental Medicine, Transplant Centre of the University Hospital Hradec Králové, Centre for Cardiovascular and Transplantation Surgery in Brno) the graft function, postoperative morbidity and mortality was evaluated.
Results:
During the study period (since September 2012), organs from three brain-dead donors as a result of methanol intoxication were retrieved in the Transplant Centre of the University Hospital Ostrava. Subsequently, six kidneys were transplanted (3 males, 3 females). Postoperative complications occurred in two patients (33.3%), one patient died (16.7%). In one case (16.7%), the graft failed. None of the graft recipients developed clinical or laboratory signs of methanol poisoning.
Conclusion:
Death due to methanol intoxication is not a contraindication to organ donation, graft function and patient survival being comparable to organs from non-intoxicated donors.
Key words:
transplantation – methanol intoxication – organ donation
Zdroje
1. KST Statistiky [on line]. 2011 [cit. 2012-12-08]. Dostupný na www: <http://www.kst.cz/web/?cat=4>.
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3. López-Navidad A, Caballero F, González-Segura C, et al. Short- and long-term success of organs transplanted from acute methanol poisoned donors. Clin Transplant 2002;16:151–62.
4. Friedlaender MM, Rosenmann E, Rubinger D, et al. Successful renal transplantation from two donors with methanol intoxication. Transplantation 1996;61:1549–52.
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10. Hantson P, Vanormelingen P, Lecomte C, et al. Fatal methanol poisoning and organ donation: experience with seven cases in a single center. Transplant Proc 2000;32:491–2.
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Štítky
Surgery Orthopaedics Trauma surgeryČlánok vyšiel v časopise
Perspectives in Surgery
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