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Mixed adenoneuroendocrine carcinoma (MANEC) of the gastrointestinal tract


Authors: R. Šefr 1;  L. Němec 1;  P. Fabian 2;  L. Fiala 1
Authors place of work: Klinika operační onkologie Masarykova onkologického ústavu Brno a LF Masarykovy univerzity přednosta: doc. MUDr. R. Šefr, Ph. D. 1;  Oddělení onkologické patologie, Masarykův onkologický ústav Brno primář: MUDr. P. Fabian, Ph. D. 2
Published in the journal: Rozhl. Chir., 2017, roč. 96, č. 1, s. 41-44.
Category: Case Report

Summary

Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumour of the gastrointestinal tract composed of adenocarcinoma and neuroendocrine carcinoma. This pathologic diagnosis was recently defined by the WHO in 2010. The tumour may appear in various levels of the digestive tract including the oesophagus, stomach, colon and appendix. Biological behaviour of MANEC seems to be quite unpredictable and the prognosis uncertain. The disease may also mimic “simple“ carcinoma. Only several tens of cases have been reported so far.

Our first case was diagnosed as gastric adenocarcinoma mimicking early gastric cancer in a 47 years old male. The second case was diagnosed incidentally in the appendix of a 69 years old female after operation for gynaecologic cancer. The disease was localised in both patients; the patients underwent radical surgical resections.

Treatment options have not been standardised yet, but aggressive therapeutic measures are recommended. The patients may benefit from multimodal anticancer therapy.

Key words:
mixed adenoneuroendocrine carcinoma – MANEC - gastric cancer – appendiceal cancer


Zdroje

1. Acosta AM, Wiley EL. Primary biliary mixed adenoneuroendocrine carcinoma (MANEC): A short review. Arch Pathol Lab Med 2016;140:1157−62.

2. Kadhim MM, Jespersen ML, Pilegaard HK, et al. Mixed adenoneuroendocrine carcinoma is a rare but important tumour found in the oesophagus. Case Rep Gastrointest Med 2016;2016:9542687.

3. Brathwaite S, Rock J, Yearsley MM, et al. Mixed adeno-neuroendocrine carcinoma: An aggressive clinical entity. Ann Surg Oncol 2016;23:2281−6.

4. Max N, Rothe A, Langner C. Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A case report. Mol Clin Oncol 2016;5:95−8.

5. Cordier R. Les cellules argentaffines dans les tumeurs intestinales. Arch Int Med Exp 1924;1: 59.

6. Bosman FT, Carneiro F, Hruban RH, et al. WHO classification of tumours of the digestive system. 4th ed. Lyon, IARC Press 2010:64−8.

7. Fukuba N, Yuki T, Ishihara S, et al. Gastric mixed adenoneuroendocrine carcinoma with a good prognosis. Intern Med 2014;53: 2585−8.

8. Gurzu S, Kadar Z, Bara T, et al. Mixed adenoneuroendocrine carcinoma of gastrointestinal tract: report of two cases. World J Gastroenterol 2015;21:1329−33.

9. Apostolidis L, Bergmann F, Jaeger D, et al. Treatment outcomes of patients with mixed adenoneuroendocrine carcinoma (MANEC). J Clin Oncol 2015; 33 (suppl abstr e15187).

10. Sakatani A, Shinzaki S, Hayashi Y, et al. A case of gastric mixed adenoneuroendocrine carcinoma with difficulty in diagnosis before endoscopic submucosal dissection. Nihon Shokakibyo Gakkai Zasshi 2016;113:1909−15 (abstract).

11. Connor SJ, Hanna GB, Frizelle FA. Appendiceal tumors: retrospective clinicopathologic analysis of appendiceal tumors from 7,970 appendectomies. Dis Colon Rectum 1998;41:75−80.

12. Koshy R, Allam H. Gastric mixed adeno-neuroendocrine carcinoma (MANEC) – A case & review. Eur J Surg Oncol 2014;40:156.

Štítky
Surgery Orthopaedics Trauma surgery
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