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preLekára.sk / Journals / Perspectives in Surgery / 2019 - 12

Adipose tissue collection from a living kidney donor; an experimental model for the research of atherosclerosis

Česká verzia

Authors: F. Thieme 1,2;  L. Janoušek 1,2;  A. Králová 3;  S. Čejková 3;  I. Králová Lesná 3;  R. Poledne 3;  J. Froněk 1,2,4
Authors place of work: Klinika transplantační chirurgie, Institut klinické a experimentální medicíny, Praha 1;  1. lékařská fakulta Univerzity Karlovy, Praha 2;  Laboratoř pro výzkum aterosklerózy, Institut klinické a experimentální medicíny, Praha 3;  Ústav anatomie, 2. lékařská fakulta Univerzity Karlovy, Praha 4
Published in the journal: Rozhl. Chir., 2019, roč. 98, č. 12, s. 476-480.
Category: Review
doi: https://doi.org/10.33699/PIS.2019.98.12.476–480

Summary

Thanks to an increased number of living-donor kidney transplants the IKEM transplant program offers the possibility of obtaining adipose tissue for scientific purposes from patients with varying degrees of atherosclerosis. Surgery mainly addresses vascular complications of this disease. On the other hand, surgery may also be the reason for the development and acceleration of atherosclerosis – for instance, acceleration of atherosclerosis in the living kidney donor, particularly if, although meeting internationally recognized donation criteria, the donor actually suffers from metabolic syndrome. The effort to refine the examinations of living kidney donors in terms of eliminating the risk of developing atherosclerosis is a long-term project. The aims are to determine the risk factors for living kidney donors and to prevent long-term complications after donation. The paper gives a detailed description of the technique of adipose tissue collection from a living kidney donor and of the experimental model for the research of atherosclerosis.The project has the potential to increase the safety of living kidney donation and to enhance our present knowledge of atherosclerosis development mechanisms.

Keywords:

Atherosclerosis – perivascular adipose tissue – living-donor kidney transplant – metabolic syndrome

Zdroje
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Perspectives in Surgery

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