Phyllodes tumours – a retrospective review of 83 clinical cases

Česká verzia

Authors: P. Mužlayová ¹; O. Coufal ^2,3,4 ; P. Fabian ⁵; A. Svobodník ⁶; O. Zapletal ²
Authors place of work: Lékařská fakulta Masarykovy Univerzity, Brno ¹; Klinika operační onkologie, Masarykův onkologický ústav, Brno ²; Klinika operační onkologie lékařské fakulty Masarykovy univerzity, Brno ³; Regionální centrum aplikované molekulární onkologie (RECAMO), Brno ⁴; Oddělení onkologické patologie, Masarykův onkologický ústav, Brno ⁵; Mezinárodní centrum klinického výzkumu Fakultní nemocnice u sv. Anny v Brně ⁶
Published in the journal: Rozhl. Chir., 2019, roč. 98, č. 9, s. 362-369.
Category: Original articles
doi: https://doi.org/10.33699/PIS.2019.98.9.362–369

Summary

Introduction: Phyllodes tumours are rare, accounting for 0.3–1.0% of all primary breast tumours. According to biological behaviour, they are divided into three categories: benign, borderline and malignant. Due to the rare incidence, the requirements for the radicality of surgical treatment are not well known. According to respected foreign recommendations, resection with a free margin of 10 mm or more is desirable.Methods: A retrospective review of patients, who underwent surgical treatment due to phyllodes tumour in the Masaryk Memorial Cancer lnstitute in 2003–2014.

Results: 83 patients were evaluated with a median follow-up of 68.0 months. Benign tumours accounted for 62.3%, borderline tumours accounted for 16.9% and malignant accounted for 20.8% of all tumours. Malignant phyllodes tumours reached a bigger average size (84.9 mm) than borderline (41.4 mm) and benign tumours (33.3 mm) and occurred in older patients (mean 56.4 years) than benign (mean 42.5 years). Results from preoperative core-cut biopsy were often inaccurate. In 70 cases, the primary resection was breast preserving, but the free margin above 1 mm was achieved only in 13 cases. The width of the resection edge never exceeded the recommended 10 mm. Nevertheless, there was a relapse in benign tumours in two cases and in the borderline tumours only in one case. Malignant tumours recurred more frequently, even after total mastectomy. Four patients with malignant tumours experienced distant metastases. There has never been a death caused by benign or borderline tumour.

Conclusion: The 10 mm resection margin is unachievable in our conditions. However, it seems that such radicality is not necessary in benign tumours, because they rarely recur even with close margins. Conversely, neither total mastectomy of the malignant phyllodes tumours will protect against local progression or distant metastasis.

Keywords:

surgery – recurrence – phyllodes tumour – margin of excision

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