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Native nephrectomy in patients with autosomal dominant polycystic kidney disease in the kidney transplant program – single-center retrospective results of 2000−2020


Authors: P. Navrátil 1,2,3;  J. Špaček 1,3;  M. Balík 1,3;  I. Novák 1,2,3;  J. Pacovsky 1,2,3;  P. Navrátil st. 1,2,3;  I. Guňka 2,3,4
Authors place of work: Urologická klinika, Fakultní nemocnice Hradec Králové 1;  Mezioborové transplantační centrum Hradec Králové 2;  Lékařská fakulta Univerzity Karlovy v Hradci Králové 3;  Chirurgická klinika, Fakultní nemocnice Hradec Králové 4
Published in the journal: Rozhl. Chir., 2023, roč. 102, č. 1, s. 11-16.
Category: Original articles
doi: https://doi.org/10.33699/PIS.2023.102.1.11–16

Summary

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease that leads to chronic renal failure in about half of patients. It is a multisystemic disease with a predominance of kidney involvement, which significantly worsens the patient’s health. Controversial issues include the indication and the timing and technique of nephrectomy of native polycystic kidneys.

Methods: A retrospective observational study focused on the surgical aspects of patients with ADPKD who underwent native nephrectomy at our institution. The group included patients operated on in the period 1/1/2000–31/12/2020. A total of 115 patients with ADPKD were enrolled (14.7% of all transplant recipients). We evaluated the basic demographic data, type of surgery, indications and complications in this group.

Results: Native nephrectomy was performed in 68 out of a total of 115 (59%) patients. Unilateral nephrectomy was done in 22 (32%) patients and bilateral in 46 (68%). The most common indications were infections (42 patients, 36%), pain (31 patients, 27%), hematuria (14 patients, 12%), gastrointestinal reasons (1 patient, 1%), respiratory reasons (1 patient, 1%), obtaining a site for transplantation (17 patients, 15%) and suspected tumor (5 patients, 4%).

Conclusion: Native nephrectomy is recommended in symptomatic kidneys, or in asymptomatic kidneys when it is necessary to obtain a place for kidney transplantation, and in kidneys where a tumor is suspected.

Keywords:

kidney transplantation – ADPKD – autosomal dominant polycystic kidney disease – native nephrectomy


Zdroje

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11. D. Cohen, Timsit MO, Chrétien Y, et al. Place of nephrectomy in patients with autosomal dominant polycystic kidney disease waiting for renal transplantation. [Article in French] Prog Urol. 2008;18:642–649. doi:10.1016/j. purol.2008.06.004.

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Štítky
Surgery Orthopaedics Trauma surgery

Článok vyšiel v časopise

Perspectives in Surgery

Číslo 1

2023 Číslo 1
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