Biological therapy in women with inflammatory bowel disease during pregnancy

Česká verzia

Authors: Jana Koželuhová; Karel Balihar; Eva Janská; Lucie Fremundová; Martin Matějovič
Authors place of work: Gastroenterologické a hepatologické oddělení I. interní kliniky LF UK a FN Plzeň, přednosta prof. MUDr. Martin Matějovič, Ph. D.
Published in the journal: Prakt Gyn 2014; 18(3): 190-194
Category: Gynecology and Obstetrics: Review Article

Summary

The aim of this article is to objective review available research data regarding the safety of biological therapies during pregnancy and breastfeeding in women with inflammatory bowel disease. Biological therapies appear to be safe in pregnancy, as no increased risk of malformations has been demonstrated. Available clinical results suggest that the efficacy of infliximab and adalimumab in achieving clinical response and maintaining remission in pregnant patients might outweigh the theoretical risks of drug exposure to the fetus. If possible, anti-TNF therapy should be stopped by the end of the second trimester due to transplacental transfer and potential risk for the fetus. The use of infliximab and adalimumab is probably compatible with breastfeeding.

Key words:
adalimumab – breastfeeding – inflammatory bowel disease – infliximab – pregnancy

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