Preparation and Therapeutic Use of Granulocytes
Príprava a liečebné použitie granulocytov
Transfúzie granulocytov sú jednou z možností ovplyvnenia závažných infekčných komplikácií granulocytopénie. V 80. rokoch sa táto liečba prakticky prestala používať pre nejednoznačné liečebnévýsledky pri používaní koncentrátov s relatívne malým obsahom granulocytov. V 90. rokoch sa obnovilzáujem o transfúzie granulocytov, nakoľko v tomto období sa darí získavať koncentráty s podstatnevyšším obsahom granulocytov vďaka používaniu rekombinantného granulocytového rastového faktorana mobilizáciu neutrofílie u darcov. V literárnom prehľade sa uvádzajú súčasné možnosti produkciegranulocytových koncentrátov, mobilizácie granulocytov u darcov, komplikácie hemaferézy, kvalitazískavaných koncentrátov, súčasný pohľad na liečebné využitie granulocytov ako aj komplikácie tejtoliečby.
Klíčová slova:
granulocytopénia, leukaferéza, transfúzia granulocytov, G-CSF
Authors:
E. Fehérvízyová
Authors‘ workplace:
Klinika hematológie a transfuziológie, FN, Bratislava
Published in:
Transfuze Hematol. dnes,, 2000, No. 1, p. 5-10.
Category:
Overview
Granulocyte transfusions are one of the possibilities how to influence serious infectious complicationsof granulocytopenia. In the eighties this treatment was practically abandoned because of the equivocaltherapeutic results when concentrates with a relatively small amount of granulocytes were used. Inthe nineties the interest in granulocyte transfusions increased as during that peri od it proved possibleto obtain concentrates with a substantially higher granulocyte content due to the recombinant granu-locyte growth factor for the mobilization of neutrophilia in donors. In the review of the literature theauthor mentions contemporary possibilities of production of granulocyte concentrates, mobilizationof granulocytes in donors, complications of haemapheresis, quality of the obtained concentrates,contemporary views on the therapeutic use of granulocytes as well as complications of treatment.
Key words:
granulocytopenia, leukapheresis, granulocyte transfusion, G-CSF
Labels
Haematology Internal medicine Clinical oncologyArticle was published in
Transfusion and Haematology Today
2000 Issue 1
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