COMBINATION THERAPY OF BENIGN PROSTATIC HYPERPLASIA – CLINICAL APLLICATIONS

Česká verzia

Published in the journal: Urol List 2011; 9(4): 49-53

Summary

Benign prostatic hyperplasia (BPH) is the main cause of lower urinary tract symptoms in older men. Since introduction of α-adrenoreceptor antagonists (α-blockers) and 5α-reductase inhibitors, medical therapy has become the first-line treatment of BPH. Positive effect of either of the drug classes on relief of symptoms and clinical progression has led to combination therapy research, which, as proven by large clinical trials, is superior to monotherapy in terms of reducing the risk of acute urinary retention, BPH-related surgery and clinical progression in patients at risk. The article provides complex data on combination therapy with α-blockers and 5α-reductase inhibitors based on results of two long-term, randomized, double-blind trials: MTOPS (The Medical Therapy of Prostatic Symptoms) a CombAT (The Combination of Avodart^®and Tamsulosin).

Key words:
benign prostatic hyperplasia, combination therapy

Zdroje

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