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CURRENT MANAGEMENT OF ADULT NEUROGENIC BLADDER – A REVIEW


Authors: H. Tunuguntla;  Y. Suk Kwon
Authors place of work: Section of Voiding Dysfunction, Neuro-Urology, Female Pelvic Medicine and Reconstructive Surgery, and Urodynamics ;  Rutgers, the State University of New Jersey, Robert Wood Johnson Medical School ;  Division of Urological Surgery
Published in the journal: Urol List 2015; 13(3): 14-21

Summary

In this review, the authors sought to present different patterns of voiding abnormalities and conventional and emerging treatment options in order to provide timely information for urologists who seek to opti­mize their care for patients with neurogenic lower urinary tract dysfunction. Management options of proven benefit in neurogenic lower urinary tract dysfunction are not uniformly utilized effectively. As significant and rapid advances in therapy have been made in the field of urodynamics in the past two decades, it is becom­ing increasingly important for clinicians to gain a deeper understanding of complex disease mechanisms associated with neurogenic lower urinary tract dysfunction and to develop appropriate treatment strategies accordingly. Adult neurogenic lower urinary tract dysfunction is a very common urological condition affect­ing men and women worldwide occurring in patients with central, peripheral, autonomic or ­mixed neurological conditions. In this up to date treatise, basic and urodynamic evaluation of pa­tients with various neurogenic lower urinary tract conditions is discussed along with non-pharmacological, pharmacological, minimally invasive, and reconstructive surgical treatment options. Lower urinary tract dysfunction in common neurogenic problems including cerebrovascular accidents, Parkinson‘s disease, multiple sclerosis, brain tumors, spinal cord injury, myelodysplasia, spinal cord tumors, herniated intervertebral disk, peripheral nerve injury, cauda equina syndrome, conus medullaris syndrome, among others are discus­sed. Contemporary advances in the management of adult neurogenic lower urinary tract dysfunction as practiced in academic centers worldwide in 2015 have been presented in this review. Current ­emphasis on the practical and clinical classification of neurogenic lower urinary tract dysfunction into a low and high risk category and utilization of such categorization in the management of patients with neurogenic lower urinary tract dysfunction has been discussed. Regular and lifelong urological follow up can preserve the upper urinary tract, improve the outcomes, prevent complications, and potentially result in an optimized quality of life and life expectancy.

Key words:
spinal cord injuryneurogenic bladderdetrusor sphincter dyssynergianeurogenic lower urinary tract dysfunctionurodynamicsvoiding dysfunction


Zdroje

1. Sorokin I, De E. Options for independent bladder management in patients with spinal cord injury and hand function prohibiting intermittent catheterization. Neurourol Urodyn 2015; 34(2): 167–176. doi: 10.1002/nau.22516.

2. Consortium for Spinal Cord Medicine. Bladder man­agement for adults with spinal cord injury: a clinical practice guideline for health-care providers. J Spinal Cord Med 2006; 29(5): 527–573.

3. McGuire EJ, Woodside JR, Borden TA et al. Prognostic value of urodynamic testing in myelodysplastic patients. J Urol 1981; 126(2): 205–209.

4. Lapides J, Diokno AC, Silber SM et al. Clean, intermittent self-catheterization in the treatment of urinary tract disease. J Urol 2002; 167(4): 1584–1586.

5. Dorsher PT, McIntosh PM. Neurogenic bladder. Adv Urol 2012; 2012: 816274. doi: 10.1155/2012/816274.

6. Cameron AP, Wallner LP, Tate DG et al. Bladder management after spinal cord injury in the United States 1972 to 2005. J Urol 2010; 184(1): 213–217. doi: 10.1016/j.juro.2010.03.008.

7. Abrams P, Agarwal M, Drake M et al. A pro­posed guideline for the urological management of pa­tients with spinal cord injury. BJU Int 2008; 101(8): 989–994. doi: 10.1111/j.1464-410X.2008.07457.x.

8. Razdan S, Leboeuf L, Meinbach DS et al. Current practice patterns in the urologic surveillance and man­agement of patients with spinal cord injury. Urology 2003; 61(5): 893–896.

9. Singh G, Thomas DG. The female tetraplegic: an admission of urological failure. Br J Urol 1997; 79(5): 708–712.

10. Jackson AB, Dijkers M, Devivo MJ et al. A demographic profile of new traumatic spinal cord injuries: change and stability over 30 years. Arch Phys Med Rehabil 2004; 85(11): 1740–1748.

11. Bennett CJ, Young MN, Adkins RH et al. Comparison of bladder management complication outcomes in female spinal cord injury patients. J Urol 1995; 153(5): 1458–1460.

12. Pan D, Troy A, Rogerson J et al. Long-term outcomes of external sphincterotomy in a spinal in­jured population. J Urol 2009; 181(2): 705–709. doi: 10.1016/j.juro.2008.10.004.

13. Yang CC, Mayo ME. External urethral sphincterotomy: long-term follow-up. Neurourol Urodyn 1995; 14(1): 25–31.

14. Eastwood EA, Hagglund KJ, Ragnarsson KT et al. Medical rehabilitation length of stay and outcomes for persons with traumatic spinal cord injury – 1990–1997. Arch Phys Med Rehabil 1999; 80(11): 1457–1463.

15. Kessler TM, Ryu G, Burkhard FC. Clean inter­mittent self-catheterization: a burden for the patient? Neurourol Urodyn 2009; 28(1): 18–21. doi: 10.1002/nau.20610.

16. Dmochowski RR, Ganabathi K, Leach GE. Non-operative management of the urinary tract in spinal cord injury. Neurourol Urodyn 1995; 14(1): 47–55.

17. Wyndaele JJ, Madersbacher H, Kovindha A. Conservative treatment of the neuropathic bladder in spinal cord injured patients. Spinal Cord 2001; 39(6): 294–300.

18. Warren JW. Catheter-associated urinary tract infections. Int J Antimicrob Agents 2001; 17(4): 299–303.

19. Morton SC, Shekelle PG, Adams JL et al. Antimicrobial prophylaxis for urinary tract infection in persons with spinal cord dysfunction. Arch Phys Med Rehabil 2002; 83(1): 129–138.

20. Esclarín De Ruz A, García Leoni E, Herruzo Cabrera R. Epidemiology and risk factors for urinary tract infection in patients with spinal cord injury. J Urol 2000; 164(4): 1285–1289.

21. West DA, Cummings JM, Longo WE et al. Role of chronic catheterization in the development of bladder cancer in patients with spinal cord injury. Urology 1999; 53(2): 292–297.

22. Sugimura T, Arnold E, English S et al. Chronic suprapubic catheterization in the management of patients with spinal cord injuries: analysis of ­upper and lower urinary tract complications. BJU Int 2008; 101(11): 1396–1400. doi: 10.1111/j.1464-410X.2007.07404.x.

23. Mitsui T, Minami K, Furuno T et al. Is suprapubic cystostomy an optimal urinary management in high quadriplegics? A comparative study of suprapubic cystostomy and clean intermittent catheterization. Eur Urol 2000; 38(4): 434–438.

24. Yavuzer G, Gok H, Tuncer S et al. Compliance with bladder management in spinal cord injury patients. Spinal Cord 2000; 38(12): 762–765.

25. Kass EH. Asymptomatic infections of the urinary tract. Trans Assoc Am Physicians 1956; 69: 56–64.

26. Nickel JC, Grant SK, Costerton JW. Catheter--associated bacteriuria. An experimental study. Urology 1985; 26(4): 369–375.

27. Liedl B. Catheter-associated urinary tract infec­tions. Curr Opin Urol 2001; 11(1): 75–79.

28. Warren JW. The catheter and urinary tract infection. Med Clin North Am 1991; 75(2): 481–493.

29. Katsumi HK, Kalisvaart JF, Ronningen LD et al. Urethral versus suprapubic catheter: choosing the best bladder management for male spinal cord injury patients with indwelling catheters. Spinal Cord 2010; 48(4): 325–329. doi: 10.1038/sc.2009.134.

30. Weld KJ, Dmochowski RR. Effect of bladder man­agement on urological complications in spinal cord injured patients. J Urol 2000; 163(3): 768–772.

31. Hadley EC. Bladder training and related therapies for urinary incontinence in older people. JAMA 1986; 256(3): 372–379.

32. Ersoz M, Akyuz M. Bladder-filling sensation in patients with spinal cord injury and the potential for sensation-dependent bladder emptying. Spinal Cord 2004; 42(2): 110–116.

33. Stohrer M, Blok B, Castro-Diaz D et al. EAU guide­lines on neurogenic lower urinary tract dysfunction. Eur Urol 2009; 56(1): 81–88. doi: 10.1016/j.eururo.2009.04.028.

34. del Popolo G, Mencarini M, Nelli F et al. Controversy over the pharmacological treatments of storage symptoms in spinal cord injury patients: a literature overview. Spinal Cord 2012; 50(1): 8–13. doi: 10.1038/sc.2011.110.

35. Benner JS, Nichol MB, Rovner ES et al. Patient--reported reasons for discontinuing overactive bladder medication. BJU Int 2010; 105(9): 1276–1282. doi: 10.1111/j.1464-410X.2009.09036.x.

36. O’Leary M, Erickson JR, Smith CP et al. Effect of controlled-release oxybutynin on neurogenic bladder function in spinal cord injury. J Spinal Cord Med 2003; 26(2): 159–162.

37. Tyagi P, Thomas CA, Yoshimura N et al. Investigations into the presence of functional Beta1, Beta2 and Beta3-adrenoceptors in urothelium and detrusor of human bladder. Int Braz J Urol 2009; 35(1): 76–83.

38. Yamaguchi O. Beta3-adrenoceptors in human detrusor muscle. Urology 2002; 59 (Suppl 1): 25–29.

39. Cruz F, Herschorn S, Aliotta P et al. Efficacy and safety of onabotulinumtoxinA in patients with urinary incontinence due to neurogenic detrusor overactivity: a randomized, double-blind, placebo-controlled trial. Eur Urol 2011; 60(4): 742–750. doi: 10.1016/j.eururo.2011.07.002.

40. Ginsberg D, Gousse A, Keppenne V et al. Phase 3 efficacy and tolerability study of onabotulinum­toxinA for urinary incontinence from neurogenic detrusor overactivity. J Urol 2012; 187(6): 2131–2139. doi: 10.1016/j.juro.2012.01.125.

41. Abrams P, Blaivas JG, Stanton SL et al. Sixth report on the standardisation of terminology of lower urinary tract function. Procedures related to neuro­physiological investigations: electromyo­graphy, nerve conduction studies, reflex latencies, evoked potentials and sensory testing. The International Continence Society Committee on Standardization of Terminology, New York, May 1985. Scand J Urol Nephrol 1986; 20(3): 161–164.

42. Cox L, Cameron AP. OnabotulinumtoxinA for the treatment of overactive bladder. Res Rep Urol 2014; 6: 79–89. doi: 10.2147/RRU.S43125.

43. Grosse J, Kramer G, Stohrer M. Success of repeat detrusor injections of botulinum a toxin in patients with severe neurogenic detrusor overactivity and incontinence. Eur Urol 2005; 47(5): 653–659.

44. Mehta S, Hill D, McIntyre A et al. Meta-analysis of botulinum toxin A detrusor injections in the treat­ment of neurogenic detrusor overactivity after spinal cord injury. Arch Phys Med Rehabil 2013; 94(8): 1473–1481. doi: 10.1016/j.apmr.2013.04.011.

45. Dykstra DD, Sidi AA. Treatment of detrusor-sphincter dyssynergia with botulinum A toxin: a ­double-blind study. Arch Phys Med Rehabil 1990; 71(1): 24–26.

46. Ross JC, Damanski M, Gibbon N. Resection of the external urethral sphincter in the paraplegic; preliminary report. J Urol 1958; 79(4): 742–746.

47. Reynard JM, Vass J, Sullivan ME et al. Sphincterotomy and the treatment of detrusor-sphincter dyssynergia: current status, future prospects. Spinal Cord 2003; 41(1): 1–11.

48. Chancellor MB, Bennett C, Simoneau AR et al. Sphincteric stent versus external sphincterotomy in spinal cord injured men: prospective randomized multicenter trial. J Urol 1999; 161(6): 1893–1898.

49. Wilson TS, Lemack GE, Dmochowski RR. UroLume stents: lessons learned. J Urol 2002; 167(6): 2477–2480.

50. Catz A, Luttwak ZP, Agranov E et al. The role of external sphincterotomy for patients with a spinal cord lesion. Spinal Cord 1997; 35(1): 48–52.

51. Fontaine E, Hajri M, Rhein F et al. Reappraisal of endoscopic sphincterotomy for post-traumatic neuro­genic bladder: a prospective study. J Urol 1996; 155(1): 277–280.

52. Carrion HM, Brown BT, Politano VA. External sphincterotomy at the 12 o’clock position. J Urol 1979; 121(4): 462–463.

53. Ricottone AR, Pranikoff K, Steinmetz JR et al. Long-term follow-up of sphincterotomy in the treat­ment of autonomic dysreflexia. Neurourol Urodyn 1995; 14(1): 43–46.

54. Santiago JA. Sphincterotomy failure. J Am Paraplegia Soc 1993; 16(3): 164–168.

55. Kiviat MD. Transurethral sphincterotomy: relationship of site of incision to postoperative potency and delayed hemorrhage. J Urol 1975; 114(3): 399–401.

56. Vapnek JM, Couillard DR, Stone AR. Is sphincterotomy the best management of the spinal cord injured bladder? J Urol 1994; 151(4): 961–964.

57. Chartier-Kastler EJ, Mongiat-Artus P, Bitker MO et al. Long-term results of augmentation cystoplasty in spinal cord injury patients. Spinal Cord 2000; 38(8): 490–494.

58. Gurung PM, Attar KH, Abdul-Rahman A et al. ­Long-­term outcomes of augmentation ileocystoplasty in patients with spinal cord injury: a minimum of 10 years of follow-up. BJU Int 2012; 109(8): 1236–1242. doi: 10.1111/j.1464-410X.2011.10509.x.

59. Clark K. Ileal conduit urinary diversion in adults with acquired neurogenic bladder. J Trauma 1962; 2: 142–146.

60. Leadbetter WF, Shaffer FG. Ileal loop diversion; its application to the treatment of neurogenic bladder dysfunction. J Urol 1956; 75(3): 470–479.

61. Chartier-Kastler EJ, Mozer P, Denys P et al. Neuro­genic bladder management and cutaneous non-continent ­ileal conduit. Spinal Cord 2002; 40(9): 443–448.

62. Madersbacher S, Schmidt J, Eberle JM et al. Long-term outcome of ileal conduit diversion. J Urol 2003; 169(3): 985–990.

63. Hellenthal NJ, Short SS, O’Connor RC et al. Incontinent ileovesicostomy: long-term outcomes and complications. Neurourol Urodyn 2009; 28(6): 483–486. doi: 10.1002/nau.20695.

64. Gonzalez R, Merino FG, Vaughn M. Long-term results of the artificial urinary sphincter in male pa­tients with neurogenic bladder. J Urol 1995; 154(2): 769–770.

65. Daneshmand S, Ginsberg DA, Bennet JK et al. Puboprostatic sling repair for treatment of urethral incompetence in adult neurogenic incontinence. J Urol 2003; 169(1): 199–202.

66. Abdul-Rahman A, Attar KH, Hamid R et al. Long-term outcome of tension-free vaginal tape for treat­ing stress incontinence in women with neuropathic bladders. BJU Int 2010; 106(6): 827–830. doi: 10.1111/j.1464-410X.2010.09203.x.

67. Ginsberg DA. Indications and complications of cystectomy in patients with neurogenic bladder. J Urol 2010; 184(1): 10–11. doi: 10.1016/j.juro.2010.04.024.

68. Groah SL, Weitzenkamp DA, Lammertse DP et al. Excess risk of bladder cancer in spinal cord injury: evidence for an association between indwelling catheter use and bladder cancer. Arch Phys Med Rehabil 2002; 83(3): 346–351.

69. Cameron AP, Rodriguez GM, Schomer KG. Systematic review of urological follow-up after spinal cord injury. J Urol 2012; 187(2): 391–397. doi: 10.1016/j.juro.2011.10.020.

70. Linsenmeyer MA, Linsenmeyer TA. Accuracy of bladder stone detection using abdominal x-ray after spinal cord injury. J Spinal Cord Med 2004; 27(5): 438–442.

71. Blok B, Pannek J, Castro-Diaz D et al. Guidelines on neuro-urology. European Association of Urology 2015. [online]. Available from: http://uroweb.org/wp-content/uploads/21-Neuro-Urology_LR2.pdf.

Štítky
Paediatric urologist Urology
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