Fecal calprotectin level correlated with both endoscopic severity and disease extent in ulcerative colitis

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Background:
The relationship between fecal calprotectin (FC) and disease extent in ulcerative colitis (UC) has not been fully elucidated. The aim of this study was to clarify the correlation of FC with disease extent and severity in UC patients.

Methods:
UC patients scheduled to undergo an ileocolonoscopy were enrolled and fecal samples for FC measurement were collected prior to the procedure. A Mayo endoscopic subscore (MES) was determined for each of 5 colonic segments. To evaluate the association of FC with extent of affected mucosa as well as disease severity, we assessed the correlation of FC level with the sum of MES (S-MES) for the 5 colonic segments as compared to the maximum score of MES (M-MES).

Results:
FC measurements in conjunction with findings from 136 complete colonoscopies in 102 UC patients were evaluated. FC level showed a stronger correlation with S-MES (correlation coefficient r = 0.86, p < 0.001) as compared to M-MES (r = 0.79, p < 0.001). In patients with an M-MES of 1, 2, and 3, FC level showed a significant correlation with S-MES (r = 0.67, p < 0.001; r = 0.70, p < 0.001; r = 0.47, p = 0.04, respectively). Our findings indicate that FC level is elevated in patients with greater areas of affected mucosa even in those with the same M-MES value.

Conclusions:
FC level was shown to be correlated with the extent of affected mucosa as well as severity in UC patients, thus it is useful for precise assessment of mucosal inflammation.

Keywords:
Ulcerative colitis, Fecal calprotectin, Disease extent

Autoři: Kousaku Kawashima ¹; Shunji Ishihara ^1*; Takafumi Yuki ¹; Nobuhiko Fukuba ¹; Naoki Oshima ¹; Hideaki Kazumori ²; Hiroki Sonoyama ¹; Noritsugu Yamashita ¹; Yasumasa Tada ¹; Ryusaku Kusunoki ¹; Akihiko Oka ¹; Yoshiyuki Mishima ¹; Ichiro Moriyama ^1,3; Yoshikazu Kinoshita ¹
Působiště autorů: Department of Internal Medicine II, Shimane University Faculty of Medicine, 89-1, Enya-cho, Izumo, Shimane 69 -8501, Japan. ¹; Division of Internal Medicine, Matsue Seikyo General Hospital, 8-8-8, Nishitsuda, Matsue 690-8522, Japan. ²; Cancer center, Shimane University Hospital, 89-1, Enya-cho, Izumo, Shimane 693-8501, Japan. ³
Vyšlo v časopise: BMC Gastroenterology 2016, 16:47
Kategorie: Research article
prolekare.web.journal.doi_sk: https://doi.org/10.1186/s12876-016-0462-z

© 2016 Kawashima et al.
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
The electronic version of this article is the complete one and can be found online at: http://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-016-0462-z

Souhrn

Conclusions:
FC level was shown to be correlated with the extent of affected mucosa as well as severity in UC patients, thus it is useful for precise assessment of mucosal inflammation.

Keywords:
Ulcerative colitis, Fecal calprotectin, Disease extent

Zdroje

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