Fatty acids – 2. Clinical and physiological significance

Česká verzia

Authors: E. Tvrzická; B. Staňková; M. Vecka; A. Žák
Authors place of work: Univerzita Karlova v Praze, 1. lékařská fakulta, IV. interní klinika VFN
Published in the journal: Čas. Lék. čes. 2009; 148: 116-123
Category: Přehledový článek

Summary

Fatty acids play multiple roles in humans and other organisms. In triglycerides they are the source of metabolic energy, in adipose tissue they serve also as temperature and mechanical isolators, in the form of phospholipids they are structural components of membranes. Fatty acids originating from the sn-2 glycerol carbon of phosphatidylcholine can influence the activity of diglycerides as second messengers. Unsaturated FA with 18-20 carbon atoms are precursors of prostaglandins, leucotrienes and thromboxanes, which have a broad scale of regulatory properties and have autocrine as well as paracrine effects. Fatty acids are ligands of several nuclear receptors, which take part in the subcellular control of a number of metabolic pathways. Covalent modification of proteins by FA (acylation) enables FA incorporation into the membranes. Number of pathological stages is accompanied with changes in fatty acid composition, often expressed as decreased content of unsaturated and increased content of saturated fatty acids (e.g. dyslipidemia, malnutrition, inflammation and inherited diseases). Polyunsaturated fatty acids as dietary supplements are used in prevention and in the therapy of cardiovascular diseases and other metabolic disturbances.

Key words:
fatty acids, membranes, eicosanoids, metabolism.

Zdroje

1. Nelson DL Cox, MM. Lipid Biosynthesis. In: Principles of Biochemistry. New York: W.H. Freeman and Company 2005; 787–815.

2. Nelson DL, Cox MM. Lipids. In: Principles of Biochemistry. New York: W.H. Freeman and Company 2005; 343–363.

3. Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 1955; 34: 1345–1355.

4. Smith WL. Nutritionally essential fatty acids and biologically indispensable cyclooxygenases. Trends Biochem. Sci 2008; 33: 27–37.

5. Berdyshev EV, Boichotb E, Lagenteb V. Anandamide – a new look on fatty acid ethanolamides. J Lipid Mediat Cell Signal 1996; 15: 49–67.

6. Praticė D, Lawson JA, Rokach J, et al. The isoprostanes in biology and medicine. Trends Endocrinol Metab 2001; 12: 243–247.

7. Haeggström JZ, Wetterholm A. Enzymes and receptors in the leukotriene cascade. Cell Mol Life Sci 2002; 59: 742–753.

8. Resh MD. Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. Biochim Biophys Acta 1998; 1451: 1–16.

9. Burr ML, Fehily AMI, Gilbert JF, et al. Effects of changes in fat, fish, and fibre intake on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 1989; II: 757–761.

10. Lorgeril de M, Salen P, Martin JL, et al. Mediterranean diet, traditional risk factors and the rate of cardiovascular complications after myocardial infarction. Final report of the Lyon Diet Heart Study. Circulation 1999; 99: 779–785.

11. GISSI-Prevenzione Investigators: Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999; 354: 447–455.

12. Chapkin RS, McMurray DN, Davidson LA, et al. Bioactive dietary long-chain fatty acids: emerging mechanisms of action. Br J Nutr 2008; 20: 1–6.

13. Montecucco F, Steffens S, Mach F. Insulin resistance: a proinflammatory state mediated by lipid-induced signaling dysfunction and involved in atherosclerotic plaque instability. Mediators Inflamm 2008; doi: 10.1155/2008/767623.

14. Lapillone A, Clarke SD, Herd WC. Polyunsaturated fatty acids and gene expression. Curr Opin Clin Nutr Metab Care 2004; 7: 151–156.

15. Pertwee RG. Ligands that target cannabinoid receptors in the brain: from THC to anandamide and betone. Addict Biol 2008; 13: 147–159.

16. Hannuksela ML, Liisanantti MK, Nissinen AE, et al. Biochemical markers of alcoholism. Clin Chem Lab Med 2007; 45: 953–961.

17. Chao W, Olson MS. Platelet-activating factor: receptors and signal transduction. Biochem J 1993; 292: 617–629.

18. Bennett MV, Verselis VK. Biophysics of gap junctions. Semin. Cell Biol 1992; 3: 29–47.

19. Lombardi F, Terranova P. Anti-arrhythmic properties of N-3 poly-unsaturated fatty acids (n-3 PUFA). Curr Med Chem 2007; 14: 2070–2080.

20. Brenner RR. Factors Influencing Fatty Acid Chain Elongation and Desaturation. In: Vergroesen AJ, Crawford M. eds. The role of fats in human nutrition. London: Academic Press 1989; 45–79.

21. Žák A, Jáchymová M, Tvrzická E, et al. The influence of polymorphism of – 493G/T MTP gene promoter and metabolic syndrome on lipids, fatty acids and oxidative stress. J Nutr Biochem 2008; 19: 634–641.

22. Žák A, Vecka M, Tvrzická E, et al. Composition of plasma fatty acids and non-cholesterol sterols in anorexia nervosa. Physiol Res 2005; 54: 443–451.

23. Burr GO, Burr MM. A new deficiency disease produced by the rigid exclusion of fat from the diet. J Biol Chem 1929; 82: 345–367.

24. Kinsella JE, Broughton S, Whelan JW. Dietary unsaturated fatty acids: interactions and possible needs in relation to eicosanoid synthesis. J Nutr Biochem 1990; 1: 123–141.

25. Crawford MA, Doyle W, William G, et al. The role of fats and EFAs for energy an cell structures in the growth of fetus and neonate. In: Vergroesen AJ, Crawford M. eds. The role of fats in human nutrition. London: Academic Press 1989; 82–116.

26. Seo T, Blanek WS, Deckelbaum RJ. Omega-3 fatty acids: molecular approaches to optima biological outcomes. Curr Opin Lipidol 2005; 16: 11–18.

27. Mead JF. In: Holman RT. ed. Progress in the Chemistry of Fats and Other Lipids. Oxford: Pergamon Press 1971; 161–189.

28. Dyerberg J. Linolenate-derived polyunsaturated fatty acids and prevention of atherosclerosis. Nutr Rev 1986; 44: 125–134.

29. Feskens EJ, Virtanen SM, Rasanen L, et al. Dietary factors determining diabetes and impaired glucose tolerance. A 20 year follow up of Finnish and Dutch Cohorts in Sevens Countries Study. Diabetes Care 1995; 18: 1104–1112.

30. Holman RT, Johnson SB, Hatch TE. A case of human linolenic acid deficiency involving neurological abnormalities. Am J Clin Nutr 1982; 35: 617–623.

31. Tvrzická E, Staňková B, Vecka M, Žák A. Mastné kyseliny. 1. Výskyt a biologický význam. Čas lék čes 2009; 148: 16–24.

32. Gadek JE, DeMichele SJ, Karlstad MD, et al. Effect of enteral feeding with eicosapentaenoic acid, γ-linolenic acid and antioxidants in patients with acute respiratory distress syndrome. Crit Care 1999; 27: 1409–1420.

33. Martinez M. The fundamentals and practice of docosahexaenoic acid therapy in peroxisomal disorders. Curr Opin Clin Nutr Metab Care 2000; 3: 101–108.

34. Oberkofler H, Liu YM, Esterbauer H, et al. Uncoupling protein-2 gene: reduced mRNA expression in intraperitoneal adipose tissue of obese humans. Diabetologia 1998; 41: 940–946.

35. Kenler AS, Swails WS, Driscoll DS, et al. Early enteral feeding in postsurgical cancer patients. Fish Oil Structured Lipid Based polymeric Formula Versus a Standard Polymeric Formula. Ann Surg 1996; 223: 316–333.

36. Clarke SD. The multi-dimensional regulation of gene expression by fatty acids: polyunsaturated fats as nutrient sensors. Curr Opin Lipidol 2004; 15: 13–18.

37. Ferdinandusse S, Denis S, Mooijer PA, et al. Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid. J Lipid Res 2001; 42: 1987–1995.

38. Dunstan J, Mori TA, Barden A, et al. Fish oil supplementation in pregnancy modifies neonatal alergen–specific immune response and clinical outcomes in infants at high risk of atopy: a randomised controlled trial. J Allergy Clin Immunol 2003; 112: 1178–1184.

39. Mihrshahi S, Peat JK, Marks GB, et al. Childhood Asthma Prevention Study. Eighteen-month outcomes of house dust mite avoidance and dietary fatty acid modification in the Childhood Asthma Prevention Study (CAPS). J Allergy Clin Immunol 2003; 111: 162–168.

40. Colomer R, Moreno-Nogueira JM, García-Luna PP, et al. N‑3 fatty acids, cancer and cachexia: a systematic review of the literature. Br J Nutr 2007; 97: 823–831.

41. Smith HJ, Greenberg NA, Tisdale MJ. Effect of eicosapentaenoic acid, protein and amino acids on protein synthesis and degradation in skeletal muscle of cachectic mice. Br J Cancer 2004; 91: 408–412.

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