Influence of Ganoderma lucidum (Curt.: Fr.) P. Karst. on T-cell-mediated immunity in normal and immunosuppressed mice line CBA/Ca

English version České info

Práce předkládá výsledky výzkumu vlivu prášku houby Ganoderma lucidum na imunitu zprostředkovanou T-buňkami u zdravých myší a myší s potlačenou imunitou linie CBA/Ca. Použita byla zkouška opožděného typu hypersenzitivity. Experimentální imunodeficience byla navozena první den pokusu intraperitoneální injekcí imunosupresivní látky cyklofosfamidu v dávce 150 mg/kg. Výsledky studie ukazují, že podání prášku Ganoderma lucidum v dávce 0,5 mg/kg perorálně po 10 dní zvyšuje odpověď opožděného typu hypersenzitivity u zdravých myší CBA/Ca. Podání 0,5 mg/kg prášku houby Ganoderma lucidum po 10 dní blokovalo rozvoj imunosuprese zprostředkované T-buňkami vyvolané podáním cyklofosfamidu a obnovilo reakci opožděného typu hypersenzitivity u myší s potlačenou imunitou.

Klíčová slova:
houba Ganoderma lucidum • cyklofosfamid • imunodeficience • imunita zprostředkovaná T-buňkám • hypersenzitivita opožděného typu

Autoři: Iryna V. Nizhenkovska; Vitalii T. Pidchenko; Nina G. Bychkova; Nina A. Bisko; Angela Y. Rodnichenko; Natalya O. Kozyko
Vyšlo v časopise: Čes. slov. Farm., 2015; 64, 139-143
Kategorie: Původní práce

Souhrn

Klíčová slova:
houba Ganoderma lucidum • cyklofosfamid • imunodeficience • imunita zprostředkovaná T-buňkám • hypersenzitivita opožděného typu

Zdroje

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