Importance of faecal calprotectin in screening and clinical assessment of adult and pediatric patients with inflammatory bowel diseases

Česká verzia

Authors: I. Čopová; O. Hradský; K. Zárubová; L. Gonsorčíková; J. Bronský
Authors place of work: Pediatrická klinika 2. LF UK a FN Motol, Praha
Published in the journal: Gastroent Hepatol 2016; 70(6): 480-484
Category: Dětská gastroenterologie a hepatologie: přehledová práce
doi: https://doi.org/doi: 10.14735/amgh2016480

Summary

Inflammatory bowel diseases (IBDs) – Crohn’s disease, ulcerative colitis, and IBD unclassified – are chronic diseases affecting the gastrointestinal tract. Their incidence, especially in the pediatric population, is growing at an alarming rate. Patients with IBD have nonspecific symptoms such as abdominal pain and chronic diarrhea. Endoscopy with sampling for histological processing is needed for diagnosis. However, this approach is invasive and requires general anesthesia in children. Additionally, endoscopy is also required during monitoring of patients with IBD to elucidate the intestinal inflammatory activity. Consequently, there is a great need for a non-invasive and sensitive marker. Fecal calprotectin is a protein that is released from the cytoplasm of activated neutrophils, and its fecal level increases during bowel inflammation. It is an ideal non-invasive biomarker with high sensitivity and specificity that enables differentiation of IBD from functional conditions such as irritable bowel syndrome, monitoring of inflammatory activity, and prediction of clinical relapse of IBD. Especially in non-symptomatic IBD, a low concentration of calprotectin in stools predicts the persistence of clinical remission. This article provides an overview of the important role of fecal calprotectin in screening and monitoring of IBD, in addition to its limitations.

Key words:
diagnosis – faecal calprotectin – monitoring – variability – inflammatory bowel diseases

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted:
20. 10. 2016

Accepted:
29. 11. 2016

Zdroje

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