Hidradenitis suppurativa, intestinal microbiome and SIBO – a comprehensive overview of the issue

Česká verzia

Authors: B. Ivanková ¹ ; J. Baloghová ^1,2
Authors place of work: Klinika dermatovenerológie UN L. Pasteura, Košice ¹; LF UPJŠ Košice ²
Published in the journal: Gastroent Hepatol 2024; 78(1): 41-46
Category: Klinická a experimentální gastroenterologie: přehledová práce
doi: https://doi.org/10.48096/ccgh202441

Summary

Hidradenitis suppurativa (HS) is a chronic immune-mediated inflammatory skin disease. It is characterized by an inflammation that affects apocrine gland bearing skin in axillae, groin and under the breasts with the formation of painful nodules, abscesses and purulent discharge, sinuses and scaring. Patients with HS have an increased incidence of inflammatory bowel disease (IBD), which also indicates their cross-sections in the pathogenesis of dysregulation congenital and adaptive immunity. Recently, there has been a significant increase of interest in the intestinal microbiome and skin disease, as much as its role in the pathogenesis of HS. According to literature, intestinal dysbiosis promotes the production of proinflammatory cytokines and consequently the formation of HS lesions. Overgrowth of bacteria in the small intestine (SIBO) is a condition characterized by an increased concentration of bacteria in the large intestine. Eradication of SIBO was able to improve psoriasis measured by the psoriasis severity index. In this context, it is hypothesized that eredication of SIBO may have a beneficial effect on the severity of manifestations in inflammatory immune-mediated skin diseases, including HS.

Keywords:

hidradenitis suppurativa – immune-mediated infl ammation – gut microbio me – small intestinal bacterial overgrowth – SIBO – interprofessional cooperation

Zdroje

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ORCID autorov

B. Ivanková 0009-0005-6036-9357,

J. Baloghová 0000-0003-4470-5777.

Doručené/ Submitted: 8. 11. 2023
Prijaté/ Accepted: 6. 1. 2024

MU Dr. Barbara Ivanková, MBA
Klinika dermatovenerológie
UPJŠ LF a UN LP Košice
Trieda SNP 1
040 01 Košice
barbara.ivankova@unlp.sk