Update on the 2016 WHO classification of tumors of the central nervous system
– Part 1: Diffusely infiltrating gliomas

Česká verzia

Authors: Marián Švajdler ^1,2; Boris Rychlý ³; Josef Zámečník ⁴; Peter Švajdler ⁵
Authors place of work: Šiklův ústav patologie, Univerzita Karlova v Praze, Lékařská fakulta v Plzni a Fakultní nemocnice Plzeň, Česká republika ¹; Bioptická laboratoř, s. r. o., Plzeň, Česká republika ²; Cytopathos s. r. o., Bratislava, Slovenská republika ³; Ústav patologie a molekulární medicíny 2. lékařské fakulty UK a FN v Motole, Praha, Česká republika ⁴; Oddelenie patológie, Univerzitná nemocnica Louisa Pasteura, Košice, Slovenská Republika ⁵
Published in the journal: Čes.-slov. Patol., 53, 2017, No. 1, p. 12-21
Category: Přehledový článek

Summary

Revised WHO 2016 classification of tumors of the central nervous system (CNS) incorporates for the first time genetic information in addition to morphology for classification of many tumor entities. One of the most important changes is restructuring the chapter of diffuse gliomas. Based on shared genetic driver mutations, diffusely infiltrating astrocytomas and oligodendrogliomas are now classified together, separately from “other” glial tumors with a more circumscribed growth pattern, different pathogenesis and clinical outcome. Diffuse gliomas can now be more objectively diagnosed and further prognostically stratified by use of a relatively small number of markers (ATRX and IDH1/2 mutations and del 1p/19q). Another newly genetically-defined and clinically relevant entity is diffuse midline glioma, H3 K27M-mutant. Some glioma entities, variants and growth patterns were deleted and new variants, such as epithelioid glioblastoma and glioblastoma with a primitive neural component were added. In the article, the most important changes of diffuse gliomas classification are summarized and a practical diagnostic approach is illustrated.

Keywords:
astrocytoma – oligodendroglioma – glioblastoma – classification – IDH – ATRX

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