Bacteria of the Burkholderia cepacia complex: epidemiology and diagnosis of infection in patients with cystic fibrosis
Authors:
P. Dřevínek
Authors place of work:
Ústav lékařské mikrobiologie 2. lékařské fakulty Univerzity Karlovy a Fakultní nemocnice v Motole
Published in the journal:
Epidemiol. Mikrobiol. Imunol. 63, 2014, č. 1, s. 18-26
Category:
Souhrnná sdělení, původní práce, kazuistiky
Summary
Bacteria of the Burkholderia cepacia complex are the cause of severe lung infections primarily in patients with cystic fibrosis (CF). The risk of epidemic spread of the pathogen in the community of CF patients was the reason for implementing strict isolation measures and identifying the bacterium as early as possible. This review article features the taxonomy of the Burkholderia cepacia complex, possibilities for the laboratory diagnosis of all representatives of this complex, and epidemiological situation in the communities of CF patients in the Czech Republic and in the world.
Keywords:
Burkholderia cepacia complex - cystic fibrosis – epidemic strain – pathogenesis of the infection
Zdroje
1. Balascakova M, Holubova A, Skalicka V, Zemkova D, et al. Pilot newborn screening project for cystic fibrosis in the Czech Republic: defining role of the delay in its symptomatic diagnosis and influence of ultrasound-based prenatal diagnosis on the incidence of the disease. J Cyst Fibros, 2009;8:224–227.
2. Gibson RL, Burns JL, Ramsey BW. Pathophysiology and management of pulmonary infections in cystic fibrosis. Am J Respir Crit Care Med, 2003;168: 918–951.
3. Hauser AR, Jain M, Bar-Meir M, McColley SA. Clinical significance of microbial infection and adaptation in cystic fibrosis. Clin Microbiol Rev, 2011;24:29–70.
4. Isles A, Maclusky I, Corey M, Gold R, et al. Pseudomonas cepacia infection in cystic fibrosis: an emerging problem. J Pediatr, 1984;104:206–210.
5. Ratjen F, Munck A, Kho P, Angyalosi G. Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis: the ELITE trial. Thorax, 2010;65:286–291.
6. Taccetti G, Bianchini E, Cariani L, Buzzetti R et al. Early antibiotic treatment for Pseudomonas aeruginosa eradication in patients with cystic fibrosis: a randomised multicentre study comparing two different protocols. Thorax, 2012;67:853–859.
7. Dřevínek P, Fila L. Role moderní mikrobiologické diagnostiky v péči o pacienty s cystickou fibrózou. Česko-slovenská pediatrie, 2008;63:84–90.
8. Vandamme P, Dawyndt P. Classification and identification of the Burkholderia cepacia complex: Past, present and future. Syst Appl Microbiol, 2011;34:87–95.
9. Drevinek P, Hrbackova H, Cinek O, Bartosova J, et al. Direct PCR detection of Burkholderia cepacia complex and identification of its genomovars by using sputum as source of DNA. J Clin Microbiol, 2002;40:3485–3488.
10. Mahenthiralingam E, Bischof J, Byrne SK, Radomski C et al. DNA-Based diagnostic approaches for identification of Burkholderia cepacia complex, Burkholderia vietnamiensis, Burkholderia multivorans, Burkholderia stabilis, and Burkholderia cepacia genomovars I and III. J Clin Microbiol, 2000;38:3165-3173.
11. Drevinek P, Baldwin A, Dowson CG, Mahenthiralingam E. Diversity of the parB and repA genes of the Burkholderia cepacia complex and their utility for rapid identification of Burkholderia cenocepacia. BMC Microbiol, 2008;8:44.
12. Vanlaere E, Baldwin A, Gevers D, Henry D et al. Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp. nov. and Burkholderia lata sp. nov. Int J Syst Evol Microbiol, 2009;59:102–111.
13. Vanlaere E, Lipuma JJ, Baldwin A, Henry D et al. Burkholderia latens sp. nov., Burkholderia diffusa sp. nov., Burkholderia arboris sp. nov., Burkholderia seminalis sp. nov. and Burkholderia metallica sp. nov., novel species within the Burkholderia cepacia complex. Int J Syst Evol Microbiol, 2008;58:1580–1590.
14. Cesarini S, Bevivino A, Tabacchioni S, Chiarini L et al. RecA gene sequence and Multilocus Sequence Typing for species-level resolution of Burkholderia cepacia complex isolates. Lett Appl Microbiol, 2009;49:580–588.
15. Drevinek P, Mahenthiralingam E. Burkholderia. In: Fillipis de I, McKee M. Molecular Typing in Bacterial Infections. Humana Press: NY, 2013. s. 301–308.
16. Baldwin A, Mahenthiralingam E, Thickett KM, Honeybourne D, et al. Multilocus sequence typing scheme that provides both species and strain differentiation for the Burkholderia cepacia complex. J Clin Microbiol, 2005;43:4665–4673.
17. Spilker T, Baldwin A, Bumford A, Dowson CG, et al. Expanded multilocus sequence typing for Burkholderia species. J Clin Microbiol, 2009;47:2607–2610.
18. McDowell A, Mahenthiralingam E, Moore JE, Dunbar KE et al. PCR-based detection and identification of Burkholderia cepacia complex pathogens in sputum from cystic fibrosis patients. J Clin Microbiol, 2001;39:4247–4255.
19. Drevinek P, Vosahlikova S, Dedeckova K, Cinek O et al. Direct culture independent strain typing of Burkholderia cepacia complex from cystic fibrosis sputum. J Clin Microbiol, 2010;48:1888–1891.
20. Dedeckova K, Fila L, Skalicka V, Bartosova J et al. PCR detection of Burkholderia cepacia complex as one of key factors to handle a long-term outbreak. J Cyst Fibros, 2012;11:440–445.
21. Speert DP, Henry D, Vandamme P, Corey M, et al. Epidemiology of Burkholderia cepacia complex in patients with cystic fibrosis, Canada. Emerg Infect Dis, 2002;8:181–187.
22. Drevinek P, Vosahlikova S, Cinek O, Vavrova V et al. Widespread clone of Burkholderia cenocepacia in cystic fibrosis patients in the Czech Republic. J Med Microbiol, 2005;54:655–659.
23. Drevinek P, Mahenthiralingam E. Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence. Clin Microbiol Infect, 2010;16:821–830.
24. Govan JR, Brown PH, Maddison J, Doherty CJ et al. Evidence for transmission of Pseudomonas cepacia by social contact in cystic fibrosis. Lancet, 1993;342:15–19.
25. Sun L, Jiang RZ, Steinbach S, Holmes A, et al. The emergence of a highly transmissible lineage of cbl+ Pseudomonas (Burkholderia) cepacia causing CF centre epidemics in North America and Britain. Nat Med, 1995;1:661–666.
26. Holden MT, Seth-Smith HM, Crossman LC, Sebaihia M, et al. The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients. J Bacteriol, 2009;191:261–277.
27. Chen JS, Witzmann KA, Spilker T, Fink RJ, et al. Endemicity and inter-city spread of Burkholderia cepacia genomovar III in cystic fibrosis. J Pediatr, 2001;139:643–649.
28. Coenye T, Spilker T, Van Schoor A, LiPuma JJ et al. Recovery of Burkholderia cenocepacia strain PHDC from cystic fibrosis patients in Europe. Thorax, 2004;59:952–954.
29. LiPuma JJ, Spilker T, Coenye T, Gonzalez CF. An epidemic Burkholderia cepacia complex strain identified in soil. Lancet, 2002;359:2002–2003.
30. Parke JL, Gurian-Sherman D. Diversity of the Burkholderia cepacia complex and implications for risk assessment of biological control strains. Ann Rev Phytopathol, 2001;39:225–258.
31. Jones AM, Dodd ME, Govan JR, Barcus V et al. Burkholderia cenocepacia and Burkholderia multivorans: influence on survival in cystic fibrosis. Thorax, 2004;59:948–951.
32. Lipuma JJ. The changing microbial epidemiology in cystic fibrosis. Clin Microbiol Rev, 2010;23:299–323.
33. Baldwin A, Mahenthiralingam E, Drevinek P, Pope C, et al. Elucidating global epidemiology of Burkholderia multivorans in cases of cystic fibrosis by multilocus sequence typing. J Clin Microbiol, 2008;46:290–295.
34. Baldwin A, Mahenthiralingam E, Drevinek P, Vandamme P et al. Environmental Burkholderia cepacia complex isolates in human infections. Emerg Infect Dis, 2007;13:458–461.
35. Recalled wipes, swabs may contain B. cepacia. 2012. Dostupné na: http://aapnews.aappublications.org/content/early/2012/08/01/aapnews.20120801-2.full?sid=b0c5288e-3f2d-44cd-82d3-7d2e190f93d7.
36. Notice to readers: manufacturer's recall of nasal spray contaminated with Burkholderia cepacia complex. 2004. Dostupné na: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5311a8.htm.
37. Martina P, Bettiol M, Vescina C, Montanaro P, et al. Genetic diversity of Burkholderia contaminans isolates from cystic fibrosis patients in Argentina. J Clin Microbiol, 2013;51:339–344.
38. Venter JC, Remington K, Heidelberg JF, Halpern AL, et al. Environmental genome shotgun sequencing of the Sargasso Sea. Science, 2004;304:66–74.
39. Mahenthiralingam E, Baldwin A, Drevinek P, Vanlaere E, et al. Multilocus sequence typing breathes life into a microbial metagenome. PLoS ONE, 2006;1:e17.
40. Sass A, Drevinek P, Sokol PA. Comparative Transcriptomics in Burkholderia. In: Coenye T, Mahenthiralingam E. Burkholderia: From Genomes to Function. Caister Academic Press; 2014, v tisku.
41. Loutet SA, Valvano MA. A decade of Burkholderia cenocepacia virulence determinant research. Infect Immun, 2010;78:4088–4100.
42. Mahenthiralingam E, Urban TA, Goldberg JB. The multifarious, multireplicon Burkholderia cepacia complex. Nat Rev Microbiol, 2005;3:144–156.
43. Hrabák J, Zemanová A, Chudáčková E. Mobilní genetické elementy v epidemiologii rezistence bakterií k antibiotikům. Epidemiol Mikrobiol Imunol, 2010;59:55–66.
44. Mahenthiralingam E, Drevinek P. Comparative genomics of Burkholderia species. In: Coenye T, Vandamme P. Burkholderia Molecular microbiology and genomics. Norfolk: Horizon Bioscience; 2007, s. 53–79.
45. Baldwin A, Sokol PA, Parkhill J, Mahenthiralingam E. The Burkholderia cepacia epidemic strain marker is part of a novel genomic island encoding both virulence and metabolism-associated genes in Burkholderia cenocepacia. Infect Immun, 2004;72:537–547.
Štítky
Hygiena a epidemiológia Infekčné lekárstvo MikrobiológiaČlánok vyšiel v časopise
Epidemiologie, mikrobiologie, imunologie
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