Post-Embryonic Nerve-Associated Precursors to Adult Pigment Cells:
Genetic Requirements and Dynamics of Morphogenesis and
Differentiation
The pigment cells of vertebrates serve a variety of functions and generate a
stunning variety of patterns. These cells are also implicated in human
pathologies including melanoma. Whereas the events of pigment cell development
have been studied extensively in the embryo, much less is known about
morphogenesis and differentiation of these cells during post-embryonic stages.
Previous studies of zebrafish revealed genetically distinct populations of
embryonic and adult melanophores, the ectotherm homologue of amniote
melanocytes. Here, we use molecular markers, vital labeling, time-lapse imaging,
mutational analyses, and transgenesis to identify peripheral nerves as a niche
for precursors to adult melanophores that subsequently migrate to the skin to
form the adult pigment pattern. We further identify genetic requirements for
establishing, maintaining, and recruiting precursors to the adult melanophore
lineage and demonstrate novel compensatory behaviors during pattern regulation
in mutant backgrounds. Finally, we show that distinct populations of latent
precursors having differential regenerative capabilities persist into the adult.
These findings provide a foundation for future studies of post-embryonic pigment
cell precursors in development, evolution, and neoplasia.
Vyšlo v časopise:
Post-Embryonic Nerve-Associated Precursors to Adult Pigment Cells:
Genetic Requirements and Dynamics of Morphogenesis and
Differentiation. PLoS Genet 7(5): e32767. doi:10.1371/journal.pgen.1002044
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pgen.1002044
Souhrn
The pigment cells of vertebrates serve a variety of functions and generate a
stunning variety of patterns. These cells are also implicated in human
pathologies including melanoma. Whereas the events of pigment cell development
have been studied extensively in the embryo, much less is known about
morphogenesis and differentiation of these cells during post-embryonic stages.
Previous studies of zebrafish revealed genetically distinct populations of
embryonic and adult melanophores, the ectotherm homologue of amniote
melanocytes. Here, we use molecular markers, vital labeling, time-lapse imaging,
mutational analyses, and transgenesis to identify peripheral nerves as a niche
for precursors to adult melanophores that subsequently migrate to the skin to
form the adult pigment pattern. We further identify genetic requirements for
establishing, maintaining, and recruiting precursors to the adult melanophore
lineage and demonstrate novel compensatory behaviors during pattern regulation
in mutant backgrounds. Finally, we show that distinct populations of latent
precursors having differential regenerative capabilities persist into the adult.
These findings provide a foundation for future studies of post-embryonic pigment
cell precursors in development, evolution, and neoplasia.
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