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STAT Is an Essential Activator of the Zygotic Genome in the Early
Embryo


In many organisms, transcription of the zygotic genome begins during the

maternal-to-zygotic transition (MZT), which is characterized by a dramatic

increase in global transcriptional activities and coincides with embryonic stem

cell differentiation. In Drosophila, it has been shown that

maternal morphogen gradients and ubiquitously distributed general transcription

factors may cooperate to upregulate zygotic genes that are essential for pattern

formation in the early embryo. Here, we show that Drosophila

STAT (STAT92E) functions as a general transcription factor that, together with

the transcription factor Zelda, induces transcription of a large number of

early-transcribed zygotic genes during the MZT. STAT92E is present in the early

embryo as a maternal product and is active around the MZT. DNA–binding

motifs for STAT and Zelda are highly enriched in promoters of early zygotic

genes but not in housekeeping genes. Loss of Stat92E in the

early embryo, similarly to loss of zelda, preferentially

down-regulates early zygotic genes important for pattern formation. We further

show that STAT92E and Zelda synergistically regulate transcription. We conclude

that STAT92E, in conjunction with Zelda, plays an important role in

transcription of the zygotic genome at the onset of embryonic development.


Vyšlo v časopise: STAT Is an Essential Activator of the Zygotic Genome in the Early Embryo. PLoS Genet 7(5): e32767. doi:10.1371/journal.pgen.1002086
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1002086

Souhrn

In many organisms, transcription of the zygotic genome begins during the

maternal-to-zygotic transition (MZT), which is characterized by a dramatic

increase in global transcriptional activities and coincides with embryonic stem

cell differentiation. In Drosophila, it has been shown that

maternal morphogen gradients and ubiquitously distributed general transcription

factors may cooperate to upregulate zygotic genes that are essential for pattern

formation in the early embryo. Here, we show that Drosophila

STAT (STAT92E) functions as a general transcription factor that, together with

the transcription factor Zelda, induces transcription of a large number of

early-transcribed zygotic genes during the MZT. STAT92E is present in the early

embryo as a maternal product and is active around the MZT. DNA–binding

motifs for STAT and Zelda are highly enriched in promoters of early zygotic

genes but not in housekeeping genes. Loss of Stat92E in the

early embryo, similarly to loss of zelda, preferentially

down-regulates early zygotic genes important for pattern formation. We further

show that STAT92E and Zelda synergistically regulate transcription. We conclude

that STAT92E, in conjunction with Zelda, plays an important role in

transcription of the zygotic genome at the onset of embryonic development.


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Štítky
Genetika Reprodukčná medicína

Článok vyšiel v časopise

PLOS Genetics


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