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It's All in the Timing: Too Much E2F Is a Bad Thing


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Vyšlo v časopise: It's All in the Timing: Too Much E2F Is a Bad Thing. PLoS Genet 8(8): e32767. doi:10.1371/journal.pgen.1002909
Kategorie: Perspective
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1002909

Souhrn

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Zdroje

1. BiswasAK, JohnsonDG (2012) Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage. Cancer Res 72(1) 13–17.

2. StevensC, La ThangueNB (2004) The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair (Amst) 3(8–9): 1071–1079.

3. AsanoM, NevinsJR, WhartonRP (1996) Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev 10(11): 1422–32.

4. ShibutaniS, SwanhartLM, DuronioRJ (2007) Rbf1-independent termination of E2f1-target gene expression during early Drosophila embryogenesis. Development 134: 467–478.

5. ShibutaniST, de la CruzAF, TranV, TurbyfillWJ3rd, ReisT, et al. (2008) Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase. Dev Cell 15(6): 890–900.

6. DavidsonJM, DuronioRJ (2012) S phase-coupled E2f1 destruction ensures homeostasis in proliferating tissues. PLoS Genet 8(8): e1002831 doi:10.1371/journal.pgen.1002831.

7. Tanaka-MatakatsuM, XuJ, ChengL, DuW (2009) Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev Biol 326(2): 347–356.

8. MoonNS, Di StefanoL, MorrisEJ, PatelR, WhiteK, et al. (2008) E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet 4(8): e1000153 doi:10.1371/journal.pgen.1000153.

9. KrekW, XuG, LivingstonDM (1995) Cyclin A-kinase regulation of E2F1 DNA binding function underlies suppression of an S-phase checkpoint. Cell 83(7): 1149–1158.

10. CampaneroMR, FlemingtonEK (1997) Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor protein. Proc Natl Acad Sci U S A 94(6): 2221–2226.

Štítky
Genetika Reprodukčná medicína

Článok vyšiel v časopise

PLOS Genetics


2012 Číslo 8
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Autori: MUDr. Tomáš Ürge, PhD.

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