Mouse Y-Encoded Transcription Factor Is Essential for Sperm Formation and Function in Assisted Fertilization

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The mammalian Y chromosome was once thought to be a genetic wasteland with testis determinant Sry being the only gene of importance. We now know that there are many genes on this chromosome crucial for male reproduction but their specific roles are often undefined. Here, we investigated the function of the Y chromosome gene Zfy2 during a final step of male gamete formation. We demonstrated that Zfy2 is responsible for allowing sperm precursor cells, haploid round spermatids, to undergo transformation into spermatozoa, and that these sperm are capable of yielding live offspring when injected into the oocytes. Thus, we identified a novel role of the Zfy2 gene during spermatogenesis and fertilization. Considering that in human sperm formation is a prerequisite for male infertility treatment using assisted reproduction technologies, our finding bear translational significance.

Vyšlo v časopise: Mouse Y-Encoded Transcription Factor Is Essential for Sperm Formation and Function in Assisted Fertilization. PLoS Genet 11(12): e32767. doi:10.1371/journal.pgen.1005476
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005476

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