Predicting the Epidemic Sizes of Influenza A/H1N1, A/H3N2, and B: A Statistical Method
Background:
The epidemic sizes of influenza A/H3N2, A/H1N1, and B infections vary from year to year in the United States. We use publicly available US Centers for Disease Control (CDC) influenza surveillance data between 1997 and 2009 to study the temporal dynamics of influenza over this period.
Methods and Findings:
Regional outpatient surveillance data on influenza-like illness (ILI) and virologic surveillance data were combined to define a weekly proxy for the incidence of each strain in the United States. All strains exhibited a negative association between their cumulative incidence proxy (CIP) for the whole season (from calendar week 40 of each year to calendar week 20 of the next year) and the CIP of the other two strains (the complementary CIP) from the start of the season up to calendar week 2 (or 3, 4, or 5) of the next year. We introduce a method to predict a particular strain's CIP for the whole season by following the incidence of each strain from the start of the season until either the CIP of the chosen strain or its complementary CIP exceed certain thresholds. The method yielded accurate predictions, which generally occurred within a few weeks of the peak of incidence of the chosen strain, sometimes after that peak. For the largest seasons in the data, which were dominated by A/H3N2, prediction of A/H3N2 incidence always occurred at least several weeks in advance of the peak.
Conclusion:
Early circulation of one influenza strain is associated with a reduced total incidence of the other strains, consistent with the presence of interference between subtypes. Routine ILI and virologic surveillance data can be combined using this new method to predict the relative size of each influenza strain's epidemic by following the change in incidence of a given strain in the context of the incidence of cocirculating strains.
: Please see later in the article for the Editors' Summary
Vyšlo v časopise:
Predicting the Epidemic Sizes of Influenza A/H1N1, A/H3N2, and B: A Statistical Method. PLoS Med 8(7): e32767. doi:10.1371/journal.pmed.1001051
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pmed.1001051
Souhrn
Background:
The epidemic sizes of influenza A/H3N2, A/H1N1, and B infections vary from year to year in the United States. We use publicly available US Centers for Disease Control (CDC) influenza surveillance data between 1997 and 2009 to study the temporal dynamics of influenza over this period.
Methods and Findings:
Regional outpatient surveillance data on influenza-like illness (ILI) and virologic surveillance data were combined to define a weekly proxy for the incidence of each strain in the United States. All strains exhibited a negative association between their cumulative incidence proxy (CIP) for the whole season (from calendar week 40 of each year to calendar week 20 of the next year) and the CIP of the other two strains (the complementary CIP) from the start of the season up to calendar week 2 (or 3, 4, or 5) of the next year. We introduce a method to predict a particular strain's CIP for the whole season by following the incidence of each strain from the start of the season until either the CIP of the chosen strain or its complementary CIP exceed certain thresholds. The method yielded accurate predictions, which generally occurred within a few weeks of the peak of incidence of the chosen strain, sometimes after that peak. For the largest seasons in the data, which were dominated by A/H3N2, prediction of A/H3N2 incidence always occurred at least several weeks in advance of the peak.
Conclusion:
Early circulation of one influenza strain is associated with a reduced total incidence of the other strains, consistent with the presence of interference between subtypes. Routine ILI and virologic surveillance data can be combined using this new method to predict the relative size of each influenza strain's epidemic by following the change in incidence of a given strain in the context of the incidence of cocirculating strains.
: Please see later in the article for the Editors' Summary
Zdroje
1. SonoguchiTNaitoHHaraMTakeuchiYFukumiH 1985 Cross-subtype protection in humans during sequential, overlapping, and/or concurrent epidemics caused by H3N2 and H1N1 influenza viruses. J Infect Dis 151 81 88
2. CowlingBJNgSMaESChengCKWaiW 2010 Protective efficacy of seasonal influenza vaccination against seasonal and pandemic influenza virus infection during 2009 in Hong Kong. Clin Infect Dis 51 1370 1379
3. FergusonNMGalvaniAPBushRM 2003 Ecological and immunological determinants of influenza evolution. Nature 422 428 433
4. TriaFLassigMPelitlLFranzS 2005 A minimal stochastic model for influenza evolution. J Stat Mech Theor Exp P07008
5. SkowronskiDMDe SerresGCrowcroftNSJanjuaNZBoulianneN 2010 Association between the 2008–09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada. PLoS Med 7 e1000258 doi:10.1371/journal.pmed.1000258
6. CDC United States Surveillance Data. Available: http://www.cdc.gov/flu/weekly/ussurvdata.htm. Accessed 1 September 2010
7. CDC Overview of Influenza Surveillance in the United States. Available: http://www.cdc.gov/flu/weekly/overview.htm#Viral. Accessed 1 December 2010
8. CDC United States Census Estimates. Available: http://wonder.cdc.gov/population.html. Accessed 1 September 2010
9. ShamanJPitzerVEViboudCGrenfellBTLipsitchM 2010 Absolute humidity and the seasonal onset of influenza in the continental United States. PLoS Biol 8 e1000316 doi:10.1371/journal.pbio.1000316
10. ShamanJGoldsteinELipsitchM 2011 Absolute humidity and pandemic versus epidemic influenza. Am J Epidemiol 173 127 135
11. BodewesRKreijtzJHRimmelzwaanGF 2009 Yearly influenza vaccinations: a double-edged sword? Lancet Infect Dis 9 784 788
12. BodewesRKreijtzJHBaasCGeelhoed-MierasMMde MutsertG 2009 Vaccination against human influenza A/H3N2 virus prevents the induction of heterosubtypic immunity against lethal infection with avian influenza A/H5N1 virus. PLoS One 4 e5538 doi:10.1371/journal.pone.0005538
13. ThompsonWWShayDKWeintraubEBrammerLCoxN 2003 Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 289 179 186
Štítky
Interné lekárstvoČlánok vyšiel v časopise
PLOS Medicine
2011 Číslo 7
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