Research questions in pre-hospital trauma care
Noting that a variety of pre-hospital interventions can now be applied to treat traumatic injury, David J Lockey calls for research to determine which of these actually improve survival and reduce morbidity.
Published in the journal:
Research questions in pre-hospital trauma care. PLoS Med 14(7): e32767. doi:10.1371/journal.pmed.1002345
Category:
Perspective
doi:
https://doi.org/10.1371/journal.pmed.1002345
Summary
Noting that a variety of pre-hospital interventions can now be applied to treat traumatic injury, David J Lockey calls for research to determine which of these actually improve survival and reduce morbidity.
The evidence base for pre-hospital trauma care
Twenty years ago, an editorial examining the evidence for, and worldwide expenditure on, pre-hospital emergency care noted that—despite considerable expenditure—the evidence base for the field was less than that of urticaria or constipation [1]. Much has been published since, but many key questions about the provision of early trauma care still have to be addressed [2].
Most advanced EMS (Emergency Medical Service) systems are designed to identify seriously injured trauma patients and transport them rapidly to a suitable hospital. Many also dispatch advanced clinical teams with extended skills to the scene. These teams provide interventions to either treat time-critical pathology or to avert deterioration or death before in-hospital interventions are available. In low- and middle-income countries, EMS infrastructure rarely allows advanced on-scene care, and basic infrastructure improvements (e.g., effective ambulance services) are a higher priority.
Advanced trauma systems are inclusive—they quality assure the whole trauma care pathway from point of injury to rehabilitation. This approach encourages parallel development of pre- and in-hospital services and increases attention on the quality of care outside the major trauma centre, usually the priority site for trauma care initiatives. “Early” trauma care interventions are often described as commencing in the receiving emergency department, but as hospital survival improves an increasing proportion of trauma deaths occur in the pre-hospital phase of care. Despite this, significant pre-hospital trauma research with potential for improving outcomes remains limited. Most pre-hospital trauma research studies are based on trauma registry data, sometimes using prospective or before-and-after study designs, and randomised trials are rare. Studies have usually focussed on which interventions deliver benefit and how they can be delivered.
What can be delivered currently?
In Europe, where pre-hospital care is frequently physician-delivered, advanced pre-hospital critical care interventions are often performed at the scene of the injury, and new interventions are reported regularly. Advanced interventions are less commonly reported in the United States, where pre-hospital care is delivered by nonphysicians. Pre-hospital anaesthesia, mechanical ventilation, chest decompression, resuscitative thoracotomy, and advanced monitoring have been performed for many years. More recently reported interventions include pre-hospital transfusion [3], extracorporeal membrane oxygenation [4], CT scanning with stroke thrombolysis [5], resuscitative endovascular balloon occlusion of the aorta [6], and point-of-care testing (e.g., ultrasound imaging, blood gas analysis, plasma lactate, and tissue oxygen saturation). This wide range of interventions indicates that, with sufficient resources and training, most in-hospital interventions can be delivered before hospital arrival.
The delivery of advanced interventions on scene is promoted on the basis that, if left untreated until hospital arrival, some patients will die or suffer morbidity from uncorrected time-critical pathology. The in-hospital intensive care principle of “critical care without walls” [7]—that patients should be treated on the basis of their compromise rather than their geographical location—can similarly be applied to pre-hospital trauma care. Airway compromise, haemorrhage and tension pneumothorax have been the focus of most time-critical interventions to date. Now that a wide range of interventions that can be applied in the pre-hospital phase of care has been established, the more difficult question of which interventions should be performed is the research challenge for the immediate future.
Key questions
True innovation is rare in pre-hospital trauma care. Most promising interventions are developed in-hospital and, where practical, translated into the pre-hospital phase of care. Major breakthroughs in pre-hospital trauma care are likely to follow the same breakthroughs in in-hospital practice—effective blood substitutes and haemostatic and neuroprotective techniques are, for example, aspirations in both areas. There are exceptions to this, and some technological advances may only be applicable in the pre-hospital phase of care. Examples include vehicle automatic crash notification technology or the use of unmanned aerial vehicles for surveillance or for the rapid delivery of equipment or interventions to the scene of injury.
Although surgical interventions receive most attention, they are the most difficult to introduce into routine pre-hospital practice, and less invasive interventions may also have the potential to improve outcomes. Technological advances make many modes of monitoring and investigation readily available to pre-hospital care providers. Diagnostic ultrasound and tissue oxygen saturation [8] are 2 examples. Pharmacological pre-hospital interventions are straightforward to administer; tranexamic acid [9] is an example of a drug reported to provide benefit when administered as early as possible after insult. Anticoagulant reversal after head injury [10] is a more recent pharmacological pre-hospital intervention. Other agents have the potential to modify the response to hypoperfusion and prevent organ damage when administered early after injury [11].
Studies in the pre-hospital phase of care may improve our understanding of the pathophysiology of hyperacute injury and yield new knowledge of which interventions might influence outcomes, and by what mechanisms. Some early mortality may only be reduced by accident prevention or mitigation techniques, but to reduce mortality on scene in those who are seriously injured requires a deeper understanding of early injury pathophysiology, the timelines of deterioration, markers of severity, and the requirement for early intervention. Current physiological markers, e.g., heart rate, blood pressure, and plasma lactate [12] are insensitive and often give little indication of which patients will deteriorate quickly. Inflammatory markers have been described as possible indicators of injury severity and prognosis but are not yet available for practical use in resuscitation.
Once efficacy has been established, the question of how interventions should be delivered is more about pre-hospital service infrastructure than the interventions themselves. Although the principles of the US model of trauma care have been influential in many countries, there is surprising variation and disagreement about how care should be delivered. Provider levels, transport methods, and triage and hospital bypass guidelines are all the subject of controversy and still require investigation to maximise benefit in resource-limited systems. In cardiac arrest research early identification, dispatcher advice and instructions to bystanders have been identified as key factors in progress [13]. Not all trauma patients have the same treatment urgency as victims of medical cardiac arrest, but many of the concepts and priorities are the same.
Barriers to conducting pre-hospital research
The barriers to effective pre-hospital trauma research are substantial. Trials involving acutely injured patients who cannot consent to treatment or trial recruitment are possible but arduous. Even well-designed randomised trials usually compromise to achieve recruitment, for example in using randomisation by provider, vehicle, or region rather than of patients [14]. The lack of standardisation in case mix, providers, timelines, and endpoints can make generalisability of results difficult. Patients with very severe injuries tend to have many interventions during their hospital stay which may vary both in, and between, trauma centres. Mortality may therefore be an insensitive outcome measure of an isolated pre-hospital intervention. Pre-hospital trauma registry studies are increasingly performed with larger patient numbers [15], but patient heterogeneity, inconsistency in the care provided, and incomplete data make interpretation of this type of study difficult—particularly with mortality as the primary outcome. Even well-funded studies can encounter major limitations when service providers do not recruit and deliver interventions consistently [16].
Conclusion
Pre-hospital trauma care is a relatively undeveloped research area. Many advanced interventions are now possible, and future studies need to establish which improve survival and reduce morbidity. Advanced surgical interventions are likely to target a small number of severely injured patients in high-income countries but have shown promise. In-hospital trauma mortality is declining, and research to target accident prevention and reduce the mortality of patients who die before reaching hospital is key to reducing overall trauma mortality.
Zdroje
1. Callaham M. Quantifying the scanty science of pre-hospital emergency care. Ann Emerg Med 1997;30:785–790. 9398774
2. The Torpo Research Collaboration, Fevang E, Lockey D, Thompson J, Lossius HM, Scand J. The top five research priorities in physician-provided pre-hospital critical care: a consensus report from a European research collaboration. Trauma Resusc Emerg Med. 2011 Oct 13;19(1):57. doi: 10.1186/1757-7241-19-57 21996444
3. Brown JB, Sperry JL, Fombona A, Billiar TR, Peitzman AB, Guyette FX. Pre-trauma center red blood cell transfusion is associated with improved early outcomes in air medical trauma patients. J Am Coll Surg. 2015 May;220(5):797–808. doi: 10.1016/j.jamcollsurg.2015.01.006 25840537
4. Lamhaut L, Jouffroy R, Soldan M, Phillipe P, Deluze T, Jaffry M, et al. Safety and feasibility of prehospital extra corporeal life support implementation by non-surgeons for out-of-hospital refractory cardiac arrest. Resuscitation. 2013 Nov;84(11):1525–9. doi: 10.1016/j.resuscitation.2013.06.003 23827888
5. Kunz A, Ebinger M, Geisler F, Rozanski M, Waldschmidt C, Weber JE, et al. Functional outcomes of pre-hospital thrombolysis in a mobile stroke treatment unit compared with conventional care: an observational registry study. Lancet Neurol. 2016 Sep;15(10):1035–43. http://dx.doi.org/10.1016/S1474-4422(16)30129-6 27430529
6. Sadek S, Lockey DJ, Lendrum RA, Perkins Z, Price J, Davies GE. Resuscitative endovascular balloon occlusion of the aorta (REBOA) in the pre-hospital setting: An additional resuscitation option for uncontrolled catastrophic haemorrhage. Resuscitation. 2016 Oct;107:135–8. doi: 10.1016/j.resuscitation.2016.06.029 27377669
7. Hillman K. Critical care without walls. Curr Opin Crit Care. 2002 Dec;8(6):594–9. 12454548
8. Arakaki LSL, Bulger EM, Ciesielski WA, Carlbom DJ, Fisk DM, Sheehan KL, et al. Muscle Oxygenation as an Early Predictor of Shock Severity in Trauma Patients. Shock. 2017 May;47(5):599–605. doi: 10.1097/SHK.0000000000000787 27820776
9. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. CRASH-2 trial collaborators, Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y et al. Lancet. 2010 Jul 3;376(9734):23–32. doi: 10.1016/S0140-6736(10)60835-5 20554319
10. Lendrum RA, Kotze JP, Lockey DJ, Weaver AE. Pre-hospital administration of prothrombin complex concentrate to the head-injured patient. Emerg Med J. 2013 Mar;30(3):247–8. http://dx.doi.org/10.1136/emermed-2012-202302 23349352
11. Sordi R, Nandra KK, Chiazza F, Johnson FL, Cabrera CP, Torrance HD, et al. Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Ann Surg. 2017 Feb;265(2):408–417. doi: 10.1097/SLA.0000000000001664 28059970
12. Guyette FX, Meier EN, Newgard C, McKnight B, Daya M, Bulger EM et al (ROC Investigators). A comparison of prehospital lactate and systolic blood pressure for predicting the need for resuscitative care in trauma transported by ground. J Trauma Acute Care Surg. 2015 Mar;78(3):600–6. doi: 10.1097/TA.0000000000000549 25710433
13. Nolan JP, Berg RA, Bernard S, Bobrow BJ, Callaway CW, Cronberg T, et al. Intensive care medicine research agenda on cardiac arrest. Intensive Care Med. 2017 Mar 11. doi: 10.1007/s00134-017-4739-7 28285322
14. Gates S, Lall R, Quinn T, Deakin CD, Cooke MW, Horton J, et al. Prehospital randomised assessment of a mechanical compression device in out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised trial and economic evaluation. Health Technol Assess. 2017 Mar;21(11):1–176. https://dx.doi.org/10.3310/hta21110 28393757
15. Galvagno SM Jr, Haut ER, Zafar SN, Millin MG, Efron DT, Koenig GJ Jr, et al. Association between helicopter vs ground emergency medical services and survival for adults with major trauma. JAMA. 2012 Apr 18;307(15):1602–10. doi: 10.1001/jama.2012.467 22511688
16. Garner AA, Mann KP, Fearnside M, Poynter E, Gebski V. The Head Injury Retrieval Trial (HIRT): a single-centre randomised controlled trial of physician prehospital management of severe blunt head injury compared with management by paramedics only. Emerg Med J. 2015 Nov;32(11):869–75. doi: 10.1136/emermed-2014-204390 25795741
Štítky
Interné lekárstvoČlánok vyšiel v časopise
PLOS Medicine
2017 Číslo 7
- Parazitičtí červi v terapii Crohnovy choroby a dalších zánětlivých autoimunitních onemocnění
- Pleiotropní účinky statinů na kardiovaskulární systém
- Statiny indukovaná myopatie: Jak na diferenciální diagnostiku?
- Zástava srdce u pacienta se střelnými ranami – kazuistika
- Statinová intolerance
Najčítanejšie v tomto čísle
- Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study
- Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines
- Patient-reported outcomes and survival in multiple sclerosis: A 10-year retrospective cohort study using the Multiple Sclerosis Impact Scale–29
- Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models