Same-day HIV testing with initiation of antiretroviral therapy versus standard care for persons living with HIV: A randomized unblinded trial

1. UNAIDS Fast-Track, Ending the AIDS Epidemic by 2030. Accessed May 24, 2017 at: http://www.unaids.org/en/resources/campaigns/World-AIDS-Day-Report-2014.

2. Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection. Recommendations for a Public Health Approach. Second Edition, World Health Organization, 2016. Accessed May 24, 2017 at: http://www.who.int/hiv/pub/arv/arv-2016/en/.

3. The INSIGHT START Study Group, Lundgren JD, Babiker AG, Gordin F, Emery S, Grund B, et al. Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection. New Engl J Med. 2015;373(9):795–807. doi: 10.1056/NEJMoa1506816 26192873

4. The TEMPRANO ANRS 12136 Study Group. A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa. New Engl J Med. 2015;373(9):808–22. doi: 10.1056/NEJMoa1507198 26193126

5. Fox MP, Rosen S. Retention of Adult Patients on Antiretroviral Therapy in Low- and Middle-Income Countries: Systematic Review and Meta-analysis 2008–2013. J Acquir Immune Defic Syndr. 2015;69(1):98–108. doi: 10.1097/QAI.0000000000000553 25942461

6. Clouse K, Pettifor AE, Maskew M, Bassett J, Van Rie A, Behets F, et al. Patient retention from HIV diagnosis through one year on antiretroviral therapy at a primary health care clinic in Johannesburg, South Africa. J Acquir Immune Defic Syndr. 2013;62(2):e39–46. doi: 10.1097/QAI.0b013e318273ac48 23011400

7. Zachariah R, Tayler-Smith K, Manzi M, Massaquoi M, Mwagomba B, van Griensven J, et al. Retention and attrition during the preparation phase and after start of antiretroviral treatment in Thyolo, Malawi, and Kibera, Kenya: implications for programmes? Trans Roy Soc Trop Med Hyg. 2011;105(8):421–30. doi: 10.1016/j.trstmh.2011.04.014 21724219

8. Rosen S, Fox MP. Retention in HIV care between testing and treatment in sub-Saharan Africa: a systematic review. PLoS Med. 2011;8(7):e1001056. doi: 10.1371/journal.pmed.1001056 21811403

9. Koenig SP, Bernard D, Devieux JG, Atwood S, McNairy ML, Severe P, et al. Trends in CD4 Count Testing, Retention in Pre-ART Care, and ART Initiation Rates over the First Decade of Expansion of HIV Services in Haiti. PLoS ONE. 2016;11(2):e0146903. doi: 10.1371/journal.pone.0146903 26901795

10. Siedner MJ, Lankowski A, Haberer JE, Kembabazi A, Emenyonu N, Tsai AC, et al. Rethinking the "pre" in pre-therapy counseling: no benefit of additional visits prior to therapy on adherence or viremia in Ugandans initiating ARVs. PLoS ONE. 2012;7(6):e39894. doi: 10.1371/journal.pone.0039894 22761924

11. Rosen S, Maskew M, Fox MP, Nyoni C, Mongwenyana C, Malete G, et al. Initiating Antiretroviral Therapy for HIV at a Patient's First Clinic Visit: The RapIT Randomized Controlled Trial. PLoS Med. 2016;13(5):e1002015. doi: 10.1371/journal.pmed.1002015 27163694

12. Jani IV, Sitoe NE, Alfai ER, Chongo PL, Quevedo JI, Rocha BM, et al. Effect of point-of-care CD4 cell count tests on retention of patients and rates of antiretroviral therapy initiation in primary health clinics: an observational cohort study. Lancet. 2011;378(9802):1572–9. doi: 10.1016/S0140-6736(11)61052-0 21951656

13. UNAIDS—Haiti profile. Accessed May 24, 2017 at: http://www.unaids.org/en/regionscountries/countries/haiti.

14. International Human Development Indicators, Haiti Country Profile. United Nations Development Program. Accessed May 24, 2017 at: http://hdr.undp.org/en/countries/profiles/HTI.

15. Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection. Recommendations for a Public Health Approach. World Health Organization, 2013. Accessed May 24, 2017 at: http://www.who.int/hiv/pub/guidelines/arv2013/en/.

16. Balfour L, Tasca GA, Kowal J, Corace K, Cooper CL, Angel JB, et al. Development and validation of the HIV Medication Readiness Scale. Assessment. 2007;14(4):408–16. doi: 10.1177/1073191107304295 17986658

17. Ware NC, Wyatt MA, Geng EH, Kaaya SF, Agbaji OO, Muyindike WR, et al. Toward an understanding of disengagement from HIV treatment and care in sub-Saharan Africa: a qualitative study. PLoS Med. 2013;10(1):e1001369. doi: 10.1371/journal.pmed.1001369 23341753

18. Bernays S, Rhodes T, Barnett T. Hope: a new way to look at the HIV epidemic. AIDS. 2007;21 Suppl 5:S5–11.

19. Barnett T, Weston M. Wealth, health, HIV and the economics of hope. AIDS. 2008;22 Suppl 2:S27–34.

20. Masquillier C, Wouters E, Mortelmans D, Booysen Fle R. Families as catalysts for peer adherence support in enhancing hope for people living with HIV/AIDS in South Africa. J Int AIDS Soc. 2014;17:18802. doi: 10.7448/IAS.17.1.18802 24702797

21. Amanyire G, Semitala FC, Namusobya J, Katuramu R, Kampiire L, Wallenta J, et al. Effects of a multicomponent intervention to streamline initiation of antiretroviral therapy in Africa: a stepped-wedge cluster-randomised trial. Lancet HIV. 2016;3(11):e539–e48. doi: 10.1016/S2352-3018(16)30090-X 27658873

22. Myer L, Zulliger R, Black S, Pienaar D, Bekker LG. Pilot programme for the rapid initiation of antiretroviral therapy in pregnancy in Cape Town, South Africa. AIDS Care. 2012;24(8):986–92. doi: 10.1080/09540121.2012.668173 22519561

23. Brown LB, Havlir DV, Ayieko J, Mwangwa F, Owaraganise A, Kwarisiima D, et al. High levels of retention in care with streamlined care and universal test and treat in East Africa. AIDS. 2016;30(18):2855–64. doi: 10.1097/QAD.0000000000001250 27603290

24. Sanne I, Orrell C, Fox MP, Conradie F, Ive P, Zeinecker J, et al. Nurse versus doctor management of HIV-infected patients receiving antiretroviral therapy (CIPRA-SA): a randomised non-inferiority trial. Lancet. 2010;376(9734):33–40. doi: 10.1016/S0140-6736(10)60894-X 20557927

25. Long L, Brennan A, Fox MP, Ndibongo B, Jaffray I, Sanne I, et al. Treatment outcomes and cost-effectiveness of shifting management of stable ART patients to nurses in South Africa: an observational cohort. PLoS Med. 2011;8(7):e1001055. doi: 10.1371/journal.pmed.1001055 21811402

26. Humphreys CP, Wright J, Walley J, Mamvura CT, Bailey KA, Ntshalintshali SN, et al. Nurse led, primary care based antiretroviral treatment versus hospital care: a controlled prospective study in Swaziland. BMC Health Serv Res. 2010;10:229. doi: 10.1186/1472-6963-10-229 20687955

27. Fairall L, Bachmann MO, Lombard C, Timmerman V, Uebel K, Zwarenstein M, et al. Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH): a pragmatic, parallel, cluster-randomised trial. Lancet. 2012;380(9845):889–98. doi: 10.1016/S0140-6736(12)60730-2 22901955

28. Tenthani L, Haas AD, Tweya H, Jahn A, van Oosterhout JJ, Chimbwandira F, et al. Retention in care under universal antiretroviral therapy for HIV-infected pregnant and breastfeeding women ('Option B+') in Malawi. AIDS. 2014;28(4):589–98. doi: 10.1097/QAD.0000000000000143 24468999

29. Fox MP, Shearer K, Maskew M, Meyer-Rath G, Clouse K, Sanne I. Attrition through Multiple Stages of Pre-Treatment and ART HIV Care in South Africa. PLOS ONE. 2014;9(10):e110252. doi: 10.1371/journal.pone.0110252 25330087

30. Mugglin C, Estill J, Wandeler G, Bender N, Egger M, Gsponer T, et al. Loss to programme between HIV diagnosis and initiation of antiretroviral therapy in sub-Saharan Africa: systematic review and meta-analysis. Trop Med Int Health. 2012;17(12):1509–20. doi: 10.1111/j.1365-3156.2012.03089.x 22994151

31. Bulletin de Surveillance, Epidemiologique VIH/SIDA, Programme National de Lutte contre les IST/VIH/SIDA, Juin, 2016.

32. Guiteau Moise C, Bellot C, Hennessey K, Rivera V, Severe P, Aubin D, et al. Retention of clinically stable ART patients in a rapid model of care in Haiti. Conference on Retroviruses and Opportunistic Infections (CROI), Boston, MA, USA, 2016.