Trauma care: Finding a better way

1. Rhee P, Joseph B, Pandit V, Aziz H, Vercruysse G, Kulvatunyou N, et al. Increasing trauma deaths in the United States. Ann Surg. 2014 Jul;260(1):13–21. doi: 10.1097/SLA.0000000000000600 24651132

2. Shackford SR, Mackersie RC, Holbrook TL, Davis JW, Hollingsworth-Fridlund P, Hoyt DB, et al. The epidemiology of trauma death: a population based analysis. Arch Surg. 1993;128:571–5. 8489391

3. CRASH-2 trial collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010;376:23–32. doi: 10.1016/S0140-6736(10)60835-5 20554319

4. Eastridge BJ, Mabry RL, Seguin P, Cantrell J, Tops T, Uribe P, et al. Death on the battlefield (2001–2011): implications for the future of combat casualty care. J Trauma Acute Care Surg. 2012;73(6 suppl 5):S431–S437. doi: 10.1097/TA.0b013e3182755dcc 23192066

5. Trakarnsanga K, Griffiths RE, Wilson MC, Blair A, Satchwell TJ, Meinders M, et al. An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells. Nat Commun. 2017 Mar 14;8:14750. doi: 10.1038/ncomms14750 28290447

6. Li Y, Alam HB. Creating a pro-survival and anti-inflammatory phenotype by modulation of acetylation in models of hemorrhagic and septic shock. Adv Exp Med Biol. 2012;710:107–33. doi: 10.1007/978-1-4419-5638-5_11 22127890

7. Halaweish I, Nikolian V, Georgoff P, Li Y, Alam HB. Creating a "Prosurvival Phenotype" Through Histone Deacetylase Inhibition: Past, Present, and Future. Shock. 2015;44 Suppl 1:6–16.

8. Shults C, Sailhamer EA, Li Y, Liu B, Tabbara M, Butt MU, et al. Surviving blood loss without fluid resuscitation. J Trauma. 2008;64:629–38. doi: 10.1097/TA.0b013e3181650ff3 18332802

9. Alam HB, Shuja F, Butt MU, Duggan M, Li Y, Zacharias N, et al. Surviving blood loss without blood transfusion in a swine poly-trauma model. Surgery. 2009;146:325–33. doi: 10.1016/j.surg.2009.04.007 19628092

10. Alam HB, Hamwi KB, Duggan M, Fikry K, Lu J, Fukudome EY, et al. Hemostatic and pharmacologic resuscitation: results of a long-term survival study in a swine polytrauma model. J Trauma. 2011;70:636–45. doi: 10.1097/TA.0b013e31820d0dcc 21610354

11. Liu Z, Li Y, Chong W, Deperalta DK, Duan X, Liu B, et al. Creating a prosurvival phenotype through a histone deacetylase inhibitor in a lethal two-hit model. Shock. 2014;41:104–8. doi: 10.1097/SHK.0000000000000074 24430491

12. Kim K, Li Y, Jin G, Chong W, Liu B, Lu J, et al. Effect of valproic acid on acute lung injury in a rodent model of intestinal ischemia reperfusion. Resuscitation. 2012;83:243–8. doi: 10.1016/j.resuscitation.2011.07.029 21824465

13. Jepsen CH, deMoya MA, Perner A, Sillesen M, Ostrowski SR, Alam HB, et al. Effect of valproic acid and injury on lesion size and endothelial glycocalyx shedding in a rodent model of isolated traumatic brain injury. J Trauma Acute Care Surg. 2014;77:292–7. doi: 10.1097/TA.0000000000000333 25058256

14. Sillesen M, Bambakidis T, Dekker SE, Fabricius R, Svenningsen P, Bruhn PJ, et al. Histone deactylase gene expression profiles are associated with outcomes in blunt trauma patients. J Trauma Acute Care Surg. 2016;80:26–33. doi: 10.1097/TA.0000000000000896 26517778

15. Sailhamer EA, Li Y, Smith EJ, Shuja F, Shults C, Liu B, et al. Acetylation: a novel method for modulation of the immune response following trauma/hemorrhage and inflammatory second hit in animals and humans. Surgery. 2008;144:204–16. doi: 10.1016/j.surg.2008.03.034 18656627

16. Jin G, Duggan M, Imam A, Demoya MA, Sillesen M, Hwabejire J, et al. Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury. J Trauma Acute Care Surg. 2012;73:1461–70. doi: 10.1097/TA.0b013e3182782641 23188239

17. Jin G, DeMoya MA, Duggan M, Knightly T, Mejaddam AY, Hwabejire J, et al. Traumatic brain injury and hemorrhagic shock: evaluation of different resuscitation strategies in a large animal model of combined insults. Shock. 2012;38:49–56. doi: 10.1097/SHK.0b013e3182574778 22575994

18. Imam AM, Jin G, Duggan M, Sillesen M, Hwabejire JO, Jepsen CH, et al. Synergistic effects of fresh frozen plasma and valproic acid treatment in a combined model of traumatic brain injury and hemorrhagic shock. Surgery. 2013;154:388–96. doi: 10.1016/j.surg.2013.05.008 23889966

19. Bambakidis T, Dekker SE, Sillensen M, Liu B, Johnson CN, Jin G, et al. Resuscitation With Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock. J Neurotrauma. 2016 Apr 8;33:1514–21. doi: 10.1089/neu.2015.4163 26905959

20. Dekker SE, Bambakidis T, Sillesen M, Liu B, Johnson CN, Jin G, et al. Effect of pharmacologic resuscitation on the brain gene expression profiles in a swine model of traumatic brain injury and hemorrhage. J Trauma Acute Care Surg. 2014;77:906–12; doi: 10.1097/TA.0000000000000345 25051383

21. Hwabejire JO, Jin G, Imam AM, Duggan M, Sillesen M, Deperalta D, et al. Pharmacologic modulation of cerebral metabolic derangement and excitotoxicity in a porcine model of traumatic brain injury and hemorrhagic shock. Surgery. 2013;154:234–43. doi: 10.1016/j.surg.2013.04.008 23889951

22. Halaweish I, Bambakidis T, Chang Z, Wei H, Liu B, Li Y, et al. Addition of low-dose valproic acid to saline resuscitation provides neuroprotection and improves long-term outcomes in a large animal model of combined traumatic brain injury and hemorrhagic shock. J Trauma Acute Care Surg. 2015;79:911–9. doi: 10.1097/TA.0000000000000789 26680134

23. Georgoff PE, Nikolian VC, Bonham T, Pai MP, Tafatia C, Halaweish I, et al. Safety and Tolerability of Intravenous Valproic Acid in Healthy Subjects: A Phase I Dose-Escalation Trial. Clin Pharmacokinet. 2017 May 11. doi: 10.1007/s40262-017-0553-1 28497259

24. Georgoff P, Halaweish I, Nikolian V, Higgins G, Bonham T, Tafatia C, et al. Alterations in the human proteome following administration of valproic acid. J Trauma Acute Care Surg. 2016;81(6):1020–1027. doi: 10.1097/TA.0000000000001249 27602906

25. Higgins GA, Allyn-Feuer A, Georgoff P, Nikolian V, Alam HB, Athey BD. Mining the topography and dynamics of the 4D Nucleome to identify novel CNS drug pathways. Methods. 2017 Apr 4. pii:S1046-2023(16)30444-3.

26. Higgins GA, Georgoff P, Nikolian V, Allyn-Feuer A, Pauls B, Higgins R, et al. Network Reconstruction Reveals that Valproic Acid Activates Neurogenic Transcriptional Programs in Adult Brain Following Traumatic Injury. Pharm Res. 2017 Mar 7. doi: 10.1007/s11095-017-2130-6 28271248

27. Alam HB, Pusateri AE, Kindzelski A, Egan D, Hoots K, Andrews MT, et al; HYPOSTAT workshop participants. Hypothermia and hemostasis in severe trauma: A new crossroads workshop report. J Trauma Acute Care Surg. 2012 Oct;73(4):809–17. doi: 10.1097/TA.0b013e318265d1b8 23026915

28. Behringer W, Safar P, Wu X, Kentner R, Radovsky A, Kochanek PM, et al. Survival without brain damage after clinical death of 60–120 minutes in dogs using suspended animation by profound hypothermia. Crit Care Med. 2003;31:1523–31. doi: 10.1097/01.CCM.0000063450.73967.40 12771628

29. Taylor MJ, Bailes JE, Elrifai AM, Shih SR, Teeple E, Leavitt ML, et al. A new solution for life without blood: asanguineous low-flow perfusion of a whole body perfusate during 3 hours of cardiac arrest and profound hypothermia. Circulation. 1995;91:431–44. 7805248

30. Alam HB, Bowyer MW, Koustova E, Gushchin V, Anderson D, Stanton K, et al. Learning and memory is preserved following induced asanguineous hyperkalemic hypothermic arrest in a swine model of traumatic exsanguination. Surgery. 2002;132:278–88. 12219024

31. Alam HB, Chen Z, Honma K, Koustova E, Querol RI, Jaskille A, et al. The rate of induction of hypothermic arrest determines the outcome in a swine model of lethal hemorrhage. J Trauma. 2004;57:961–9. 15580018

32. Alam HB, Rhee P, Honma K, Chen H, Ayuste EC, Lin T, et al. Does the rate of rewarming from profound hypothermic arrest influences the outcome in a swine model of lethal hemorrhage. J Trauma. 2006;60:134–46. doi: 10.1097/01.ta.0000198469.95292.ec 16456447

33. Alam HB, Chen Z, Li Y, Velmahos G, DeMoya M, Keller CE, et al. Profound hypothermia is superior to ultra-profound hypothermia in improving survival in a swine model of lethal injuries. Surgery. 2006;140:307–14. doi: 10.1016/j.surg.2006.03.015 16904984

34. Alam HB, Duggan M, Li Y, Spaniolas K, Liu B, Tabbara M, et al. Putting life on hold-for how long? Profound hypothermic cardiopulmonary bypass in a swine model of complex vascular injuries. J Trauma. 2008;64:912–22. doi: 10.1097/TA.0b013e3181659e7f 18404056

35. Sailhamer EA, Chen Z, Ahuja N, Velmahos GC, de Moya M, Rhee P, et al. Profound hypothermic cardiopulmonary bypass facilitates survival without a high complication rate in a swine model of complex vascular, splenic and colon injuries. J Am Coll Surg. 2007;204:642–53. doi: 10.1016/j.jamcollsurg.2007.01.017 17382224

36. Taylor MJ, Rhee P, Chen Z, Alam HB. Design of preservation solutions for universal tissue preservation in vivo: demonstration of efficacy in pre-clinical models of profound hypothermic cardiac arrest. Transplant Proc. 2005;37:303–7. doi: 10.1016/j.transproceed.2004.12.024 15808626

37. Alam HB. Translational barriers and opportunities for emergency preservation and resuscitation in severe injuries. Br J Surg. 2012 Jan;99 Suppl 1:29–39.

38. Tisherman SA, Alam HB, Rhee PM, Scalea TM, Drabek T, Forsythe RM, et al. Development of the Emergency Preservation and Resuscitation for Cardiac Arrest from Trauma (EPR-CAT) Clinical Trial. J Trauma Acute Care Surg. 2017 May 22. doi: 10.1097/TA.0000000000001585 28538639

39. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Web-based Injury Statistics Query and Reporting System (WISQARS) Nonfatal Injury Data. (2015). http://www.cdc.gov/injury/wisqars/nonfatal.html. Accessed 25 April 2017.

40. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Web-based Injury Statistics Query and Reporting System (WISQARS) Fatal Injury Data. (2015). http://www.cdc.gov/injury/wisqars/fatal.html. Accessed 25 April 2017.

41. Florence C, Simon T, Haegerich T, Luo F, Zhou C. Estimated Lifetime Medical and Work Loss Costs of Fatal Injuries—United States 2013. MMWR Morb Mortal Wkly Rep. 2015;64(38):1074–7. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6438a4.htm?s_cid=mm6438a4_w. Accessed 25 April 2017. doi: 10.15585/mmwr.mm6438a4 26421530

42. Florence C, Haegerich T, Simon T, Zhou C, Luo F. Estimated Lifetime Medical and Work Loss Costs of Emergency Department Treated Nonfatal Injuries—United States 2013. MMWR Morb Mortal Wkly Rep. 2015;64(38):1078–82. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6438a5.htm?s_cid=mm6438a5_w. Accessed 25 April 2017. doi: 10.15585/mmwr.mm6438a5 26421663

43. World Health Organization. Injuries and violence: the facts 2014. http://www.who.int/violence_injury_prevention/media/news/2015/Injury_violence_facts_2014/en/. Accessed 25 April 2017.