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Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study


Using quantitative and targeted metabolomics, Vijay Varma and colleagues identified metabolites for which brain tissue levels were associated with Alzheimer disease (AD) neuropathology and blood concentrations were associated with AD progression in prodromal and preclinical stages.


Vyšlo v časopise: Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study. PLoS Med 15(1): e32767. doi:10.1371/journal.pmed.1002482
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pmed.1002482

Souhrn

Using quantitative and targeted metabolomics, Vijay Varma and colleagues identified metabolites for which brain tissue levels were associated with Alzheimer disease (AD) neuropathology and blood concentrations were associated with AD progression in prodromal and preclinical stages.


Zdroje

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