New alirocumab dosing regimen: 300 mg every 4 weeks

Česká verzia

Authors: Petr Ošťádal
Authors place of work: Komplexní kardiovaskulární centrum, Nemocnice Na Homolce, Praha
Published in the journal: AtheroRev 2021; 6(2): 103-107
Category:

Summary

The proprotein convertase subtilisin kexin type 9 inhibitor (PCSK9) alirocumab has been used in the lipid-lowering therapy as a 75mg or 150mg subcutaneous injection given every 2 weeks. Currently, alirocumab is available also as a single 300mg injection for administration every 4 weeks. This dosing regimen is supported by clinical studies that have evaluated its pharmacodynamic profile, efficacy, safety and also technical aspects of the newly developed autoinjector. Present article summarizes the available evidence for treatment with alirocoumab 300mg every 4 weeks.

Keywords:

alirocumab – dosing regimen – proprotein convertase subtilisin kexin type 9 (PCSK9)

Zdroje

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