Residual inflammatory cardiovascular risk – diagnostic and therapeutic challenge

Česká verzia

Authors: Ján Murín ¹; Jozef Bulas ¹; Martin Wawruch ²; Udovít Gašpar ^1,3
Authors place of work: I. Interná klinika LF UK a UNB, Bratislava ¹; Ústav farmakológie a klinickej farmakológie LF UK, Bratislava ²; Fakulta zdravotníckych vied Univerzity sv. Cyrila a Metoda v Trnave ³
Published in the journal: AtheroRev 2021; 6(2): 95-98
Category: Reviews

Summary

Ischemic heart disease (IHD) is the most important disease concerning the highest mortality and morbidity among diseases in the world. We try to prevent this disease by modification of lifestyle and by treatment of traditional cardiovascular risk factors. This is nowadays not enough. Vascular inflammation seems to be a new critical factor of atherosclerotic plaque development and contributes also to plaque instability. The are some new possibilities to diagnose the presence of vascular inflammation: by serum hsCRP biomarker, by PET/CT and PET/MR examinations, by CT coronary calcium score or by CT FAI index (of changes in perivascular fat tissue around coronary arteries). If there is a presence of vascular inflammation in coronary arteries, then we should try to block it by antiinflammatory drugs (colchicin, canakinumab), because there is evidence to improve the prognosis of cardiovascular patients.

Keywords:

antiinflammatory treatment – cardiovascular events – residual inflammatory vascular risk

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