What is the impact of type 2 diabetes mellitus and increased glycaemia on cardiovascular risk?

Česká verzia

Authors: J. Perušičová
Authors place of work: Interní klinika UK 2. LF a FN Motol
Published in the journal: Kardiol Rev Int Med 2009, 11(3): 117-121
Category: Nontraditional risk factors cardiovascular disease

Summary

Hyperglycaemia is an independent risk factor for cardiovascular diseases. The very close association between type 2 diabetes mellitus and cardiovascular diseases has repeatedly been confirmed and led to a view that „diabetes is a cardiovascular disease“. More than 75% of patients with type 2 diabetes die from cardiovascular complications. Intensive hyperglycaemia treatment could play a role in preventing (or at least delaying) progression of macroangiopathic complications. The main mechanisms of proatherogenic effects of hyperglycaemia are as follows: increased formation of free radicals, protein glycation and production of glycation end‑products. The risk of elevated blood glucose levels begins at the stage of pre‑diabetes and is mainly related to increased postprandial glycaemia levels.

Keywords:
cardiabetes – dysglycaemia – hyperglycaemia

Zdroje

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