The incidence of congestive heart failure after myocardial infarction in clinical studies

Česká verzia

Authors: J. Kaňovský; J. Špinar
Authors place of work: Interní kardiologická klinika LF MU a FN Brno
Published in the journal: Kardiol Rev Int Med 2010, 12(3): 118-123

Summary

Myocardial infarction and congestive heart failure are two of the most important diagnoses in modern cardiology. The historical development of treatment of these diseases has been determined by many famous clinical trials. We analyzed 28 selected studies that investigated pharmacotherapy of myocardial infarction, dividing them to 4 main groups (beta blockers, renin-angiotensin-aldosterone system blockers, statins and antiaggregants). We see in our analysis that there is no evidence that beta blockers, hypolipidemic drugs, or antiaggregants influence the incidence of congestive heart failure. The only positive data we have is the data for renin-angiotensin-aldosterone system blockers. However, the proof is still missing that the combination of ACE inhibitors and angiotensin-receptor blockers is beneficial in comparison to monotherapy.

Keywords:
congestive heart failure – acute myocardial infarction – clinical trials – beta blockers – RAAS blockers – statins – antiaggregants

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