Latent obstruction in outflow tract of left ventricle in patient with hypertrophic cardiomyopathy

Česká verzia

Authors: K. Čurila; P. Gregor
Published in the journal: Kardiol Rev Int Med 2011, 13(1): 63-64
Category: Case report - competitive

Summary

Hypertrophic cardiomyopathy, affecting 1 in 500 adult persons, is most common heritable cardiovascular disease. It is characterized by a wide genotypic and phenotypic heterogeneity. In this paper we describe the case of 57-year-old patient with hypertrophic cardiomyopathy, who suffered serious symptoms due to latent obstruction in the outflow tract of the left cardiac ventricle. The obstruction was detected with the aid of stress echocardiography. Following optimization of pharmacotherapy, the patient’s symptoms disappeared without the need for intervention therapy.

Keywords:
hypertrophic cardiomyopathy – obstruction – gradient – angina pectoris

Zdroje

1. Gregor P, Widimský P et al. Kardiologie. Praha: Galen 1999; 449–459.

2. Maron BJ, Gardin JM, Flack JM et al. Prevalence of hypertrofic cardiomyopathy in a general population of jung adult: echokardiographic analysis of 4111 subject in KARDIA study. Circulation 1995; 92: 785–789.

3. Maron MS, Olivotto I, Zenovych AG et al. Hypertrophic cardiomyopathy is predominantly a disease of left ventricular outflow tract obstruction. Circulation 2006; 114: 2232–2239.

4. Maron MS, Olivotto I, Betocchi S. Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy. New Engl J Med 2003; 348: 295–303.

5. Elliott PM, Gimeno JR, Tome MT et al. Left ventricular outflow tract obstruction and sudden death risk in patients with hypertrophic cardiomyopathy. Eur Heart J 2006; 27: 1933–1941.

6. Nagueh SF, Ommen SR, Lakkis MN et al. Comparison of ethanol septal reduction therapy with surgical myectomy for the treatment of hypertrophic obstructive cardiomyopathy. J Am Coll Cardiol 2001; 38: 1701–1706.

7. Veselka J, Tesař D, Páleníčková J et al. Katetrizační léčba hypertrofické obstrukční kardiomyopatie. Cor Vasa 2003; 45: 80-84.

8. Pornin M, Harpey C, Allal J et al. Effects of trimetazidine on systemic hemodynamics in patients with coronary artery disease. J Mol Cell Cardiol 1990; 22 (Suppl 22): 150A.