Medicamentous treatment of pulmonary hypertension in 2011

Česká verzia

Authors: M. Aschermann; P. Jansa
Published in the journal: Kardiol Rev Int Med 2011, 13(1): 37-40
Category: From Hypertension to Heart Failure

Summary

Pulmonary hypertension is a primary illness of the pulmonary arterioles that leads to the gradual worsening of precapillary pulmonary hypertension and, if untreated, to the relatively rapid failure of the right heart ventricle and the death of the patient. Pulmonary hypertension occurs either due to unknown causes, or is associated with a known cause (systemic disease of the connective tissue, liver disease, congenital heart defects, HIV infections, anorexia). Current medicamentous treatment of pulmonary hypertension is divided into two categories: conventional (anti-coagulant treatment, calcium channel blockers, treatment for heart failure) and specific (prostanoids, antagonists of endothelin receptors, phosphodiesterases 5 inhibitors). Patients with a positive result in vasodilatory tests were marked for treatment with high doses of calcium channel blockers. Patients with a negative result in vasodilatory tests were marked for chronic anti-coagulant treatment and specific pharmacotherapy, employed as either monotherapy or combined treatment. New treatment options for pulmonary hypertension, which are currently under experimental study, include a number of substances: agonists for prostacyclin receptors, soluble guanylate cyclase activators and simulators, statins, antagonists for seratonin receptors and seratonin transporter blockers, Rho-associated protein kinase inhibitors, vasoactive intestinal peptides and tyrosine kinase inhibitors.

Keywords:
pulmonary hypertension – conventional and specific treatment – prostanoids – antagonists of endothelin receptors – antagonists for endotheline receptors – phosphodiesterases 5 inhibitors – experimental treatment options

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