Hypertriglyceridemia and cardiovascular risk

Česká verzia

Authors: T. Štulc
Published in the journal: Kardiol Rev Int Med 2012, 14(3): 157-160
Category:

Summary

Hypertriglyceridemia is a common metabolic disorderwhich is mostly associated with other components of so-called atherogenic dyslipidemia, inparticularwith HDL-cholesterol reduction. Both experimental and epidemiological studies show thatpathogenetic effects of hypertriglyceridemia are prevailingly indirect – they are intermediated by an increasedproduction of “small dense” LDL particles and remnant particles and by a reduced concentrationof HDL-cholesterol. Therefore, hypertriglyceridemia primarily marks atherogenic changes ofvarious lipoprotein particles and often also the occurrence of other components of the metabolic syndrome.The basis of hypertriglyceridemia treatment are dietary and regimen measures; if their efficacyis insufficient, the administration of fibrates or niacin can be considered.

Keywords:
triglycerides – atherogenic dyslipidemia – cardiovascular risk – atherosclerosis – epidemiology –clinical trials

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