Acute kidney failure and cardiovascular complication

Česká verzia

Authors: V. Danihel; L. Ledvinová; M. Matějovič
Published in the journal: Kardiol Rev Int Med 2012, 14(4): 251-253
Category:

Summary

Acute kidney injury is not an isolated event. Emerging evidence suggests that even mild acute kidney injury induces distant organ dysfunction to the heart, lung, liver and brain. Despite recent advances in renal replacement therapy, mortality of patients developing acute kidney injury and complicated by multiorgan dysfunction is 40–60%. It is believed that this unacceptable mortality rate stems, at least partly, from the distant organ effects of acute kidney injury. Therefore, there has been a surge of interest in elucidating mechanisms underlying complex and bidirectional nature of interconnection between acute kidney injury and distant organ dysfunction. Accumulating data indicate that acute kidney injury can trigger several immune, metabolic and humoral pathways, thus potentially contributing to distant organ dysfunction and overall morbidity and mortality. Better insights into bidirectional and synergistic pathways linking acute kidney injury and cardiovascular dysfunction might open the window for new therapeutic approaches that interrupt this vicious circle. Here, we briefly discuss the rationale for and current understanding of the bidirectional relationship between acute kidney injury and cardiovascular problems.

Keywords:
acute kidney injury – extrarenal complications – cardiorenal syndrome

Zdroje

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