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Candesartan in the treatment of hypertension and heart failure


Authors: J. Vítovec;  J. Špinar
Published in the journal: Kardiol Rev Int Med 2012, 14(4): 258-261
Category:

Summary

Candesartan is a modern AT1 receptor blocker for angiotensin II – sartans. It has favourable pharmacokinetic as well as pharmacodynamic properties. It has shown efficacy in terms of a reduction in morbidity and mortality resulting from such diseases in many clinical trials with respect to both hypertension and heart failure. A brief overview of the pharmacological effects and results of clinical trials (SCOPE, TROPHY, RESOLVED and CHARM) is presented.

Keywords:
candesartan – hypertension – heart failure


Zdroje

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8. McMurray JJ, Östergren J, Swedberg K et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet 2003; 362: 767–771.

9. Granger CB, McMurray JJ, Yusuf S et al. Effects of candesartan in patients with chronic heart failure and reduced left ventricular systolic function and intolerant to angiotensin-converting-enzyme inhibitors: the CHARM--Alternative trial. Lancet 2003; 362: 772–776.

10. Yusuf S, Pfeffer MA, Swedberg K et al. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet 2003; 362: 777–781.

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Štítky
Paediatric cardiology Internal medicine Cardiac surgery Cardiology
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