Is heart failure with preserved ejection fraction a serious illness?

Česká verzia

Authors: J. Murín ¹; M. Macháčová ²; R. Compagnon ³; J. Bulas ¹; M. Wawruch ⁴
Authors place of work: I. interná klinika LF UK a UN Bratislava ¹; Praktický lekár pre dospelých, MIMAD s. r. o., Topoľčany ²; Praktický lekár pre dospelých, MEDIROM s. r. o, Bratislava ³; Ústav klinickej farmakologie LF UK a UN Bratislava ⁴
Published in the journal: Kardiol Rev Int Med 2017, 19(3): 168-171

Summary

Heart failure today has a high prevalence and incidence. In clinical practice, we recognize two basic forms of this disease. We have little data on the causes, the pathogenesis and the way of death, especially in patients with heart failure with the left ventricle's "preserved ejection fraction". It is time to indulge this disease so that we can affect its pathogenesis, but especially morbidity and mortality. We do not know today whether the mechanisms of sudden death or fatal heart pump failure are similar to those of systolic heart failure or are different. Some clinical experience has shown that mortality in "preserved ejection fraction" heart failure as a "cardiac pump" failure is different from systolic heart failure and passes through progressive pulmonary hypertension, right ventricular failure, renal venous congestion, and subsequent renal function failure, and subsequently later via multi-organ dysfunction – failure. We present literature data from randomized clinical trials and epidemiological studies: most heart failure patients with "preserved ejection fraction" die from cardiovascular causes. However, specific causes of cardiovascular death are poorly defined in the studies. Sudden death accounts for about 30– 40% of deaths, and there are frequent non-cardiovascular deaths (about 20– 30%). The acquisition of these data is necessary in order to favorably influence the prognosis of these severely ill patients.

Keywords:
heart failure with preserved ejection fraction – mortality – clinical studies

Zdroje

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