Update of the role of Lp(a) in determination of the CV risk and methods of influencing it

Česká verzia

Authors: Zlatohlávek L.
Authors place of work: 3. interní klinika 1. LF UK a VFN, Praha
Published in the journal: Kardiol Rev Int Med 2019, 21(2): 68-69

Summary

Lipids are transported by lipoproteins in the blood system. Lipoprotein (a) is a unique lipoprotein of the human plasma discovered by Professor Kåre Berg in 1963. Lp(a) is composed of apoliprotein (a) and LDL. In comparison with the other lipoprotein particles, the lipoprotein (a) plasma level is rather constant, only slightly affected by endogenous and exogenous factors. Elevated Lp(a) levels are considered to be a risk factor for atherosclerosis and aortic stenosis. The risk level is over 50 mg/ dl. High levels of Lp(a) have been detected in elderly patients, it is possible that this protective effect supports the reparation of tissue and anticancer activity.

Keywords:

Atherosclerosis – therapy – lipoprotein (a)

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