Genetic Background of Cisplatin Induced Ototoxicity

Česká verzia

Authors: Michal Jurajda ¹ ; T. Talach ²; R. Kostřica ²; R. Lakomý ³; I. Kocák ³; M. Cvanová ⁴
Authors place of work: Ústav patologické fyziologie, LF MU Brno ¹; Klinika otorinolaryngologie a chirurgie hlavy a krku, FN u sv. Anny v Brně ²; Klinika komplexní onkologické péče, MOÚ Brno ³; Institut biostatistiky a analýz, LF a PřF MU Brno ⁴
Published in the journal: Klin Onkol 2012; 25(3): 184-187
Category: Original Articles

Summary

Background:
Cisplatin induced ototoxicity is a serious adverse effect of cisplatin therapy. Cisplatin induced ototoxicity shows significant interindividual variability. This variability is probably based on genetic background. Recent papers describe association of cisplatin ototoxicity with allelic variants of glutathion-S-transferase coding genes.

Patients and Methods:
We have analyzed 55 patients treated with cisplatin therapy without any previous hearing impairment. Audiometric examination was performed before the start of cisplatin therapy and then before and after each cycle of cisplatin. DNA isolated from peripheral blood samples was used to analyze genetic polymorphisms of selected genes coding for glutathion-S-transferases.

Results:
We have demonstrated association of early onset of cisplatin induced hearing impairment with absence of null allele of GSTT1 (p = 0.009). Both GSTM1 gene deletion and single nucleotide polymorphism in GSTP1 gene (rs1695) did not show any association with cisplatin induced ototoxicity.

Conclusion:
Early onset of cisplatin induced hearing impairment is more probable in persons with two functional alleles of GSTT1 gene.

Key words:
cisplatin – ototoxicity – DNA copy number variations – single nucleotide polymorphism

This study supported by grant IGA NS10101-4/2008.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
7. 5. 2012

Accepted:
20. 5. 2012

Zdroje

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