Hepatoblastoma, Etiology, Case Reports

Česká verzia

Authors: A. Puchmajerová ¹; A. Křepelová ¹; J. Indráková ²; R. Sítková ²; I. Balaščak ³; J. Kruseová ⁴; K. Švojgr ⁴; R. Kodet ⁵; M. Kynčl ⁶; A. Vícha ⁴; M. Macek Jr. ¹
Authors place of work: Ústav biologie a lékařské genetiky, 2. LF UK a FN v Motole, Praha ¹; Úsek molekulární biologie, Laboratoř lékařské genetiky, Laboratoře AGEL a. s., Nový Jičín ²; Novorozenecké oddělení, Gynekologicko-porodnická klinika 2. LF UK a FN v Motole, Praha ³; Klinika dětské hematologie a onkologie 2. LF UK a FN v Motole, Praha ⁴; Ústav patologie a molekulární medicíny, 2. LF UK a FN v Motole, Praha ⁵; Klinika zobrazovacích metod 2. LF UK a FN v Motole, Praha ⁶
Published in the journal: Klin Onkol 2016; 29(Supplementum 1): 78-82
Category: Review
doi: https://doi.org/10.14735/amko2016S78

Summary

Hepatoblastoma is an uncommon malignant neoplasm in general, yet, it is the most common liver malignancy in children with the incidence about one per milion children. This type of liver tumor usually occurs before the age of three years. The etiology of hepatoblastoma remains unknown. However, there are some genetic conditions known to be associated with an increased risk of developing hepatoblastoma such as Beckwith-Wiedemann syndrome, hemihypertrophy, APC-associated polyposis, α-1-antitrypsin defficiency and some metabolic disorders including tyrosinemia, galactosemia and glycogen storage disease type 1. There is a higher risk of hepatoblastoma in children with very low birthweight, children who acquire hepatitis B at an early age and children with congenital biliary atresia.

Key words:
hepatoblastoma – α-fetoprotein – Beckwith-Wiedemann syndrome – APC-associated polyposis

This work was supported by grant from Norway NF-CZ11-PDP-3-003-2014, MH ČR –RVO, UH Motol 00064203 and OPPK – CZ-2.16.//3.1.00/24022.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.

Submitted:
6. 8. 2015

Accepted:
9. 9. 2015

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