Challenges and solutions in management of cardiotoxicity induced by checkpoint inhibitors

Česká verzia

Authors: prof. MUDr. Mladosievičová Beáta, CSc. ¹; MUDr. Országhová Zuzana jr. ²; MUDr. Jablonická Magdaléna ³; MUDr. Rečková Mária, PhD. ^4,5; MUDr. Chovanec Michal ⁶; porf. MUDr. Mego Michal, PhD. ⁶
Authors place of work: Oddelenie klinickej patofyziológie, LF UK, Bratislava, Slovenská republika ¹; II. onkologická klinika LF UK a NOÚ, Bratislava, Slovenská republika ²; Onkologická klinika SZU, FNsP F. D. Roosevelta, Banská Bystrica, Slovenská republika ³; NOI, Bratislava, Slovenská republika ⁴; POKO Poprad, s. r. o., Slovenská republika ⁵
Published in the journal: Klin Onkol 2020; 33(5): 350-355
Category: Review
doi: https://doi.org/10.14735/amko2020350

Summary

Background: The use of immune checkpoint inhibitors has dramatically improved the prognosis of many cancer patients. However, their increasing use has also revealed several unexpected side effects – including cardiovascular complications. Increased attention was paid to them in recent years only, especially due to their potentially fatal character. Checkpoint inhibitors cardiotoxicity includes myocarditis, rhythm disorders (atrioventricular blocks, atrial and ventricular arrhythmias), pericarditis, myocardial infarction, left ventricular dysfunction/heart failure, dilated cardiomyopathy, cardiogenic shock and sudden cardiac death. The risk of ICI-associated cardiotoxicity is increased in patients treated with dual immune therapy, in combination with other cardiotoxic drugs, with preexisting cardiac damage, diabetes mellitus, underlying autoimmune disease and some other factors. Currently, there are no guidelines for prediction and management of ICI-associated cardiotoxicity.

Purpose: Herein, we briefly summarize the findings regarding checkpoint inhibitor-induced cardiotoxicity and provide a new definition of anti-tumor-induced myocarditis together with a suitable design for immune- induced myocarditis management prepared by experts from the field of cardiooncology.

Keywords:

myocarditis – cardiotoxicity – immunotherapy – immune checkpoint inhibitors – Adverse events

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