Squamous cell carcinoma of the colon – a case report

Česká verzia

Authors: MUDr. Jurišová Silvia ¹; MUDr. Angelis De Valentína ¹; MUDr. Makovník Marek ²; MUDr. Hlavčák Peter ³; MUDr. Janega Pavol ⁴; MUDr. Macák Dušan ⁵; MUDr. Chovanec Michal ¹; MUDr. Rejleková Katarína, PhD. ¹; doc. MUDr. PhD. Ák Pin Daniel ⁶; doc. MUDr. Mardiak Jozef, CSc. ¹; prof. MUDr. Mego Michal, PhD. ¹
Authors place of work: II. onkologická klinika LF UK a NOÚ, Bratislava, Slovenská republika ¹; Rádiologické oddelenie, NOÚ, Bratislava, Slovenská republika ²; Histopatologia, a. s., Bratislava, Slovenská republika ³; Ústav patologickej anatómie, LF UK, Bratislava, Slovenská republika ⁴; Oddelenie patologickej anatómie, NOÚ, Bratislava, Slovenská republika ⁵; Klinika chirurgickej onkológie SZU a NOÚ, Bratislava, Slovenská republika ⁶
Published in the journal: Klin Onkol 2020; 33(5): 380-384
Category: Case Report
doi: https://doi.org/10.14735/amko2020380

Summary

Background: Primary squamous cell carcinomas (SCC) of the colon are extremely rare and occur predominantly in the fifth decade of life, with a slight prevalence in men. The most common anatomical sites are the rectum and the proximal colon. Clinical signs and common diagnostic methods cannot clearly distinguish SCC from adenocarcinoma.

Methods: In this case report, we present a case of a 68-year-old patient with SCC of the cecum and colon ascendens, who was treated with resection and systemic gemcitabine- and cisplatin-based chemotherapy.

Results: A 68-year-old patient underwent right-sided hemicolectomy for cecal and colon ascendens tumor, histologically poorly differentiated epidermoid carcinoma, grade 3 with an initial stage of pT4aN1aM0. Due to local recurrence at the resection site with suspected infiltration of straight and oblique abdominal muscles, he was treated with systemic gemcitabine and cisplatin based chemotherapy with partial remission. Subsequently, the postchemotherapeutic residual tumor was radically resected, achieving complete remission of the disease, which persists for 10 months after the surgery.

Conclusion: The case emphasizes the need for a multidisciplinary treatment approach of this rare disease. Early surgery plays a key role. Although the standard chemotherapy regimen is not well defined, the use of a combination of cisplatin and gemcitabine resulted in partial remission in our patient, which in turn allowed a radical resection of the relapse and subsequently achieved complete remission of the disease.

Keywords:

squamous cell carcinoma – colorectal – systemic treatment

Zdroje

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