Solitary Fibrous Tumor of Meninges – a Case Report

Česká verzia

Authors: M. Hermanová ¹; J. Musil ²; S. Hotárková ¹; M. Duba ²; I. Zavřelová ¹
Authors place of work: Ústav patologie, LF MU a FN Brno ¹; Neurochirurgická klinika, LF MU a FN Brno ²
Published in the journal: Cesk Slov Neurol N 2007; 70/103(2): 210-213
Category: Case Report

Summary

Solitary fibrous tumor (SFT), first described as a pleural lesion, has been reported in a wide range of anatomic sites including meninges. SFTs of the central nervous system represent very rare spindle-cell mesenchymal neoplasms that usually present as the dura mater-based masses. The biological behavior of extrathoracic SFTs is unpredictable, meningeal SFTs possess malignant potential so that a careful, long-term follow up is required.

The authors have given a case of the totally resected large intracranially localised SFT of meninges clinically resembling meningioma. Immunohistochemistry has proved its important role in the differential diagnosis of this tumor and supported the morphological diagnosis of SFT.

Key words:
solitary fibrous tumor, meninges, immunohistochemistry

Zdroje

1. Klemperer P, Rabin CB. Primary neoplasms of the pleura: a report of five cases. Arch Pathol 1931; 11: 385-412.

2. Hasegawa T, Matsuno Y, Shimoda T, Hasegawa F, Sano T, Hirohashi S. Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior. Hum Pathol 1999; 30: 1464-73.

3. Carneiro SS, Scheithauer BW, Nascimento AG, Hirose T, Davis DH. Solitary fibrous tumor of the meninges: a lesion distinct from fibrous meningioma. A clinicopathologic and immunohistochemical study. Am J Clin Pathol 1996; 106: 217-24.

4. Pakasa NM, Pasquier B, Chambonniere M, Morrison AL, Khaddage A, Perret AG et al. Atypical presentation of soitary fibrous tumors of the central nervous systém: an analysis of unusual clinicopathological and outcome patterns in three new cases with a review of the literature. Virchows Arch 2005; 447: 81-6.

5. Cummings TJ, Burchette JL, McLendon RE. CD34 and dural fibroblasts: the relationship to solitary fibrous tumor and meningioma. Acta Neuropathologica 2001; 102: 349-54.

6. Graadt van Roggen JF, Hogendoorn PC. Solitary fibrous tumours: the emerging clinicopathologic spectrum of an antity and its differential diagnosis. Curr Diagn Pathol 2004; 10: 229-35.

7. Ogawa K, Tada T, Takahashi S, Sugiyama N, Inaguma S, Takahashi SS et al. Malignant solitary fibrous tumor of the meninges. Virchows Arch 2004; 444: 459-64.

8. Ng HK, Choi PC, Wong CW, To KF, Poon WS. Metastatic solitary fibrous tumor of the meninges. J Neurosurg 2000; 93: 490-3.

9. Vallat-Decouvelaere AV, Dry SM, Fletcher CDM. Atypical and malignant solitary fibrous tumors in extrathoracic locations. Evidence of their comparability to intra-thoracis tumors. Am J Surg Pathol 1998; 22: 1501-11.

10. de Leval L, Defraigne JO, Hermans G, Dome F, Boniver J, Herens C. Malignant solitary fibrous tumor of the pleura: report of a case with cytogenetic analysis. Virchows Arch 2003; 442: 388-92.