Retrospective Analysis of Visual Evoked Potentials Findings in Acute Retrobulbar Neuritis

Česká verzia

Authors: J. Szanyi ¹; M. Kuba ¹; Z. Kubová ¹; J. Kremláček ¹; J. Langrová ¹; N. Jirásková ²
Authors place of work: Ústav patologické fyziologie LF UK v Hradci Králové ¹; Oční klinika LF UK a FN Hradec Králové ²
Published in the journal: Cesk Slov Neurol N 2008; 71/104(3): 317-323
Category: Original Paper

Summary

Retrospective analysis of pattern-reversal VEPs (R-VEPs) and motion-onset VEPs (M-VEPs) was performed in 20 patients with first attack of acute Optic Neuritis (ON) subsequently monitored for 36–135 months during which Multiple Sclerosis (MS) developed and was confirmed in 10 of them. It did not develop in the other 10 during the term of the study. The groups with MS and without MS did not differ significantly in the extent of pathological VEP findings: in MS patients, R-VEPs were abnormal in 100 % and M-VEPs in 80 % and the non-MS patients exhibited pathology in 80 % of R-VEPs and in 90 % of M-VEPs. A higher risk of MS after unilateral optic neuritis was found in cases displaying pathological R-VEPs also in the non-affected eye (67 % of MS patients vs 22 % of non-MS patients). Although the inclusion of M-VEPs did not increase VEP examination sensitivity in ON patients, their use improves diagnostic reliability and enables better monitoring of the parvocellular/magnocellular system and ventral/dorsal stream involvement of the visual pathway.

Key words:
visual evoked potentials (VEPs) – optic neuritis (ON) – multiple sclerosis (MS) – magnocellular system – parvocellular system

Zdroje

1. Arnold AC. Optic neuritis. Saudi J Ophthalmol 2002; 16: 207–218.

2. Jacobs DA, Galetta SL. Multiple sclerosis and the visual system. Ophthalmol Clin North Am 2004; 17(3): 265–273.

3. Frohman EM, Frohman TC, Zee DS. The neuro-ophthalmology of multiple sclerosis. Lancet Neurol 2005; 4(2): 111–121.

4. Foroozan R, Buono LM, Savino PJ, Sergott RC. Acute demyelinating optic neuritis. Curr Opin Ophthalmol 2002; 13(6): 375–380.

5. Chen L, Lynn KG. Ocular manifestation of multiple sclerosis. Curr Opin Ophthalmol 2005; 16(5): 315–320.

6. Keltner JL, Johnson CA, Spurr JO, Beck RW. Baseline visual field profile of optic neuritis: the experience of the Optic Neuritis Treatment Trial. Optic Neuritis Study Group. Arch Ophthalmol 1993; 111(2): 231–234.

7. Keltner JL, Johnson CA, Spurr JO, Beck RW. Visual field profile of optic neuritis: one-year follow-up in the Optic Neuritis Treatment Trial. Arch Ophthalmol 1994; 112(7): 946–953.

8. Jirásková N, Rozsíval P, Taláb R. Záněty zrakového nervu – výsledky retrospektivní klinické studie. Cesk Slov Neurol N 2006; 69/102(6): 452–456.

9. Hradílek P, Vlček F, Zapletalová O, Školoudík D. Vyšetření vizuálních evokovaných potenciálů a sonografické vyhodnocení orbitální hemodynamiky u akutní unilaterální optické neuritidy. Cesk Slov Neurol N 2007; 70/103(1): 78–83.

10. Kuba M, Kubová Z. Visual evoked potentials specific for motion-onset. Doc Ophthalmol 1992; 80(1): 83–89.

11. Kubová Z, Kuba M, Spekreijse H, Blakemore C. Contrast dependence of motiononset and pattern-reversal evoked potentials. Vision Res 1995; 35(2): 197–205.

12. Bach M, Ullrich D. Motion adaptation governs the shape of motion-evoked cortical potentials. Vision Res 1994; 34(12): 1541–1547.

13. Langrová J, Kuba M, Kremláček J, Kubová Z, Vít F. Motion-onset VEPs reflect long maturation and early aging of visual motion-processing system.Vision Res 2006; 46(4): 536–544.

14. Kubová Z, Kuba M. Motion-onset VEPs Improve the Diagnostics of Multiple Sclerosis and Optic Neuritis. Sbor Ved Pr LF UK Hradec Králové 1995; 38(2): 89–93.

15. Kremláček J, Kuba M, Kubová Z, Chlubnová J. Motion-onset VEPs to translating, radial, rotating and spiral stimuli. Doc Ophthalmol 2004; 109(2): 169–175.

16. Frederiksen JL, Petera J. Serial visual evoked potentials in 90 untreated patients with acute optic neuritis. Surv Ophthalmol 1999; 44(1): 54–62.

17. Dunker S, Wiegand W. Prognostic value of magnetic resonance imaging in monosymptomatic optic neuritis. Ophthalmology 1996; 103(11): 1768–1773.

18. Kupersmith MJ, Alban T, Zeiffer B, Lefton D. Contrast-enhanced MRI in acute optic neuritis: relationship to visual performance. Brain 2002; 125(Pt 4): 812–822.

19. Optic Neuritis Study Group. The 5-year risk of MS after optic neuritis. Experience of the Optic Neuritis Treatment Trial. Neurology 1997; 49(5): 1404–1413.

20. Arnold AC. Evolving management of optic neuritis and multiple sclerosis. Am J Ophthalmol 2005; 139(6): 1101–1108.

21. Rolak LA, Beck RW, Paty DW, Tourtellotte WW, Whitaker JN, Rudick RA. Cerebrospinal fluid in acute optic neuritis: experience of the Optic Neuritis Treatment Trial. Neurology 1996; 46(2): 368–372.

22. Beck RW, Cleary PA, Backlund JC. The course of recovery after optic neuritis. The experience of the Optic Neuritis Treatment Trial. Ophthalmology 1994; 101(11): 1771–1778.

23. Keltner JL, Johnson CA, Spurr JO, Beck RW. Comparison of central and peripheral visual field properties in the Optic Neuritis Treatment Trial. Am J Ophthalmol 1999; 128(5): 543–553.

24. Beck RW, Gal RL, Bhatti MT. Visual function more than 10 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. Am J Ophthalmol 2004; 137(1): 77–83.

25. Szanyi J, Kuba M, Kremláček J, Taláb R, Žižka J. Porovnání výsledků vyšetření zrakových evokovaných potenciálů a magnetické rezonance u pacientů s roztroušenou sklerózou. Cesk Slov Neurol N 2003; 66/99(4): 258–262.

26. Electrophysiological Laboratory [online]. Last revision 23th April 2008. Dostupné z: < http://www.lfhk.cuni.cz/ELF/elf_main.html>.