Drug- Induced Systemic Lupus Erythematodes in Interferon Beta-1b Therapy – a Case Report

Česká verzia

Authors: V. Sládková; J. Mareš; B. Luběnová; K. Kollárová; R. Opavský; P. Kaňovský
Authors place of work: Ne urologická klinika LF UP a FN Olomo uc
Published in the journal: Cesk Slov Neurol N 2008; 71/104(4): 487-489
Category: Case Report

Summary

Drug‑induced systemic lupus erythematodes (SLE) is a relatively rare complicati on associ ated with certain drug therapi es. Its onset comes after months or ye ars of taking the drug, and the probability of its incidence grows with the length of medicati on and the cumulative dose of the drug. Among the symptoms of the syndrome are mainly artralgi a, myalgi a, fever, serositides, skin exanthema and the producti on of antinucle ar (ANA) antibodi es. Unlike SLE, its symptoms subside gradu ally after the withdrawal of the provoking agent. The a uthors report a case of a 43- ye ar old woman pati ent with multiple cerebrospinal sclerosis who developed drug‑induced SLE after eight ye ars of interferon beta‑1b therapy.

Key words:
multiple cerebrospinal sclerosis – interferon beta – drug-induced systemic lupus erythematodes

Zdroje

1. Havrdová E et al (eds). Ne uro imunologi e. Praha: Maxdorf 2001: 207– 232.

2. Javed A, Reder AT. Therape utic role of beta-interferons in multiple sclerosis. Pharmacol Ther 2006; 110(1): 35– 56.

3. Zdravcentra.cz [online]. Last revisi on 21st July 2008. Dostupné z: <https:/ / www.zdravcentra.cz/ >.

4. Borchers AT, Keen CL, Gershwin ME. Drug-induced lupus. Ann N Y Acad Sci 2007; 1108: 166– 182.

5. Rubin RL. Druginduced lupus. Toxicology 2005; 209(2): 135– 147.

6. Sarzi- Puttini P, Atleti F, Capsoni E, Lubrano E, Dori a A. Drug‑induced lupus erythematosus. Auto immunity 2005; 38(7): 507– 518.

7. Al- Zahrani H, Gupta V, Minden MD, Messner HA, Lipton JH. Vascular Events Associ ated with Alpha-Interferon Therapy. Le uk Lymphoma 2003; 44(3): 471– 475.

8. Brogan BL, Olsen NJ. Drug‑induced rhe umatic syndromes. Curr Opin Rhe umatol 2003; 15(1): 76– 80.

9. Drug‑induced lupus erytematosus [online]. Last revisi on 23rd June 2008. Dostupné z: <http:/ / en.wikipedi a.org/ wiki/ Drug‑induced_lupus_erythematosus>.

10. Leonard R. Amnemonic for SLE di agnostic kriteri a. Ann Rhe um Dis 2001; 60(6): 638.